activating transcription factors造句

• Alternatively, programmed cell death occurs when TRAF6 and neurotrophin receptor interacting factor ( NRIF ) are both recruited to activate c-Jun N-terminal kinase ( JNK ); which phosphorylates c-Jun . The activated transcription factor c-Jun regulates nuclear transcription to increase pro-apoptotic gene transcription.
• Little is known about the transcriptional regulation of EFS, but several transcriptional regulators for EFS have been proposed based on consensus binding sites in its promoter region for ATF ( Activating transcription factor ), NF-??, NF-??1, GATA-3, C / EBP? ( CCAAT / enhancer-binding protein alpha ), glucocorticoid receptors ? and ?, and p53.
• P38? MAPK is implicated in cell survival / apoptosis, proliferation, differentiation, migration, mRNA stability, and inflammatory response in different cell types through variety of different target molecules MK2 is one of the well-studied downstream targets of p38? MAPK . Their downstream substrates include small heat shock protein 27 ( HSP27 ), lymphocyte-specific protein1 ( LSP1 ), cAMP response element-binding protein ( CREB ), cyclooxygenase 2 ( COX2 ), activating transcription factor 1 ( ATF1 ), serum response factor ( SRF ), and mRNA-binding protein tristetraprolin ( TTP ) In addition to protein kinases, many transcription factors are downstream targets of p38? MAPK, including ATF1 / 2 / 6, c-Myc, c-FOS, GATA4, MEF2A / C, SRF, STAT1, and CHOP