The latency-associated nuclear antigen (LANA-1) or latent nuclear antigen (LNA, LNA-1), is a Kaposi's sarcoma-associated herpesvirus (KSHV) latent protein initially found by Moore and colleagues as a speckled nuclear antigen present in primary effusion lymphoma cells that reacts with antibodies from patients with KS. It is the most immunodominant KSHV protein identified by Western-blotting as 222?234 kDa double bands migrate slower than the predicted molecular weight.
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