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Introduction protein kinase c ( pkc ) is a number of serine / threonine kinase family which play central regulatory roles in a multitude of cellular processes , including cell proliferation , cell cycle progression , differentiation , apoptosis . increasing evidence from studies using in vitro and in vivo systems suggests that pkc is a key regulator of critical cell cycle transitions , including cell cycle entry and exit and the gl and g2 checkpoint
前言细胞周期是细胞增殖、分化的一个重要过程，它的启动与进程受到严格调控，参与调控的因子不仅包含起正调控作用的细胞周期素( cyclins ) 、细胞周期蛋白依赖性激酶( cyclin - dependentkinase ， cdk ) 、还有起负调控作用的cdk抑制因子( cyclin - dependentkinaseinhibitor ， cki ) 。