Objective the bioactivity of twelve novel pyridine ring derivatives of podophyllotoxin were tested against 3rd instar larvae of culex pipiens pallens 摘要目的研究新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的的毒杀活性。
The results suggest that it is possible to produce podophyllotoxin quickly by tissue culture , and provide much raw material to antitumor drugs with little damage to the natural resources 通过组织培养可在不破坏自然资源的前提下快速生产鬼臼毒素,从而为开发鬼臼毒素类抗癌药物提供大量原料。
Results from twelve novel pyridine ring derivatives of podophyllotoxin , three compounds 4 . 4 、 4 . 5 and 4 . 6 have more higher toxicities than others , and the lc50 were 1 . 66 , 3 . 96 and 1 . 54 mg / l respectively 结果12种新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀作用有明显的差异,化合物4 . 4 、 4 . 5和4 . 6的毒杀作用明显高于其它化合物。