Previous evidence showed that an increase in [ ca2 + ] cyt has been shown to be an early event in the aba signal transduction pathway , and ca2 + channels at the plasma membrane of stomatal guard cells are activated by hyperpolarization and aba Assmann已提出较为完善的气孔保卫细胞信号转导模式，但是对于aba信号转导的一些中间环节仍是人们不断探讨的问题。
These channels coupled the membrane excitability to intracellular ca2 + concentration and were believed to play an important role in intracellular signaling . ( 2 ) both unitary conductance and po of bkca channel were markedly sensitive to temperature 通道可将细胞信使cah的调节与神经元电兴奋性的调节有机的偶联起来，进一步确定了其在细胞信号转导中的重要作用。
This kind of mutation may be not only induced by dna damage but also through the epigenetic pathway other than the nuclear origin including the activation of various signal transduction pathways and altered expressions of many genes 这种突变除了可能由dna损伤途径触发外，也有可能通过非核起源的外遗传( epigenetic )途径，激活细胞信号转导通路，引起一系列基因表达的改变而最终导致突变的形成。
The effects of the variations of the initial signal proteins concentrations on the output of this system are also studied . the study demonstrates that the jak - stat signaling pathway is robust with respect to its signal time and signal duration , but sensitive with respect to its signal amplitude 我们主要考察了细胞信号转导过程中三个重要的特征量的变化，即“信号时间” signal time “信号持续时间” signal duration以及信号幅度signal amplitude 。
This kind of mutation may be not only being triggered by the signals originated from dna damage , but also by the signals of extra - nuclear origin through the epigenetic pathway including the activation of various signal transduction pathways and alterations of gene expressions 这种突变除了可能由dna损伤触发的途径外，已证明还有非核起源的信号触发的外遗传( epigenetic )途径介入，激活细胞信号转导通路，引起一系列基因表达的改变而最终导致突变的形成。
The previous studies in our laboratory have demonstrated that low concentration mnng treatment can induce nontargeted mutagensis in mammalian cells , and the mutagenesis is at least partly caused by the gene expression changes initiated with the activation of several signaling transduction pathways 我们实验室的研究证明低剂量mnng处理后的哺乳动物细胞中也存在非定标突变，并且哺乳动物细胞非定标突变的发生机制依赖于细胞信号转导通路介导的基因表达改变。
From the view of cellular rheology , we examined the influence of fluid shear stress on the metabolism , morphology , structure and function of endothelia cells in our previous research . it is first time for us to develop the research between shear stress and apoptosis . in this study , we stimulate the human umbilical venous endothelial cells ( huvec ) by lps and apply different levels of fluid shear stress to them by a parallel plate flow chamber , then observe the change of apoptosis of endothelial cells by terminal deoxynucleotidyl transferase mediated dutp nick end labeling ( tunel ) 我们从细胞力学的角度，曾对血管内皮细胞在剪切力作用下的代谢、形态、结构及功能等进行过系统研究，但剪切力与内皮细胞凋亡的相关研究尚属首次，我们希望通过探讨细胞凋亡与剪切力大小及作用时间的关系，为探索剪切力对血管内皮细胞信号转导的影响及作用机理提供有价值的参考数据和实验资料。
The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation , such as zinc finger 198 , 263 , 14 , 224 , zf6 , novel protein similar to transcriptional represser ctcf , and kruppel - like zinc finger protein ; two members of the adams ( a disintegrin and metalloprotease domain ) family ; two members of integrin family ; several proteins involved in the signal transduction , cell - cycle control , chromatin remodeling and transcription repression ; and also some proteins of cell skeleton and some with unknown functions 鉴定出的蛋白包括多个与转录调控相关的锌指蛋白，如锌指蛋白198 、 263 、 14 、 224 、 zf6 、转录抑制因子ctcf样蛋白、幻肚pple样锌指蛋白等:两个含金属蛋白酶结构域和整合素结合结构域的家族成员adam28和adam17 ;两个整合素家族成员pz整合素和含十个egf样结构域的整合素( tied ) ;与细胞信号转导通路有关的蛋白;与细胞周期调控有关的蛋白;与染色体重塑和基因转录抑制有关的蛋白;细胞骨架蛋白以及其他功能未明的蛋白等。
In addition , all of these indicators described above are difficult to target precisely to specific intracellular locations . when they are transfected into cells , they not only distributed in cytosolic compartment but also in the nucleus and this may cause some disaccuracy for real cytosolic ca2 + measurement 本文靶向性细胞ca ~ ( 2 + )荧光探针的设计合成及其在生命科学研究中的应用研究，使细胞钙的测定由单细胞水平拓展到了亚细胞水平，为更深入的细胞信号转导研究提供了可行、有效的手段。
