Embryo implantation , which is the process of blastocyst adhere and invade endometrium , consists three parts of attachment hydrolysis of extracellular matrix ( ecm ) and invasion 胚胎植入( embryoimplantation )是指胚泡附着并侵入子宫内膜的过程，由粘附、局部细胞外基质水解和侵入三部分构成。
Rt pcr showed egfr and egf gene activity were upregulated at the time of blastocyst invasion and adhension , though this upregulation was not directly reflected in an increase in bioactivity egf receptor . at meanwhile , the research of cultured endometrium cell had 本研究有助于进一步探求与子宫内膜接受性密切相关的因子在植入过程中基因表达与调控的信号转导作用，为进一步研究植入的分子机制提供理论和实践基础。
Similarly for the obese higher rates of cancer of the breast , colon , ovary , prostrate , endometrium ( the layer of tissue that lines the uterus ) , kidney and gallbladder are all being evidenced now in china and in younger patients than previously observed 同样，乳腺癌、结肠癌、卵巢癌、前列腺癌、子宫内膜癌（子宫内的一层组织） 、肾癌和胆囊癌在中国的发病率也明显上升，而且与先前的观测结果相比，患病人群更为年轻。
These interactions are primarily dependent upon the coordinated actions of ovarian progesterone and estrogen , moreover , many other factors , such as growth factors , cytokines , ecm , adhension molecules , oligosaccharides and proteases , regarded as local mediators , endometrium and embryo have also expressed some specific receptors , via intracellular signal transduction chains and express some key genes , making receptivity of the uterus and synchronized development of the embryo to the blastocyst stage 成功的植入是处于接受态的子宫内膜和具有侵入性的胚胎间的同步协调反应。植入过程受多种生长因子及其受体、细胞因子、粘附分子、蛋白水解酶、寡糖等的精细调控，通过胞内信号转导及关键基因的表达使子宫内膜发生一系列复杂变化。
Samples were taken from nonpregnant , pregnant and cultured endometrium cell , with using immunohistochemical staining , western - blot methods . to better understand this interaction , we further characterized the expression patterns of egfr messenger rnas in the mouse uterus on days 1 to 8 of pregnancy . in the present study , we found : two isofonns of non - phospho mapk was generally equally expressed in the nonpregnant and pregnant mice endometrium , and little difference among them 本研究以未孕及早孕小鼠( d1 ? d8 )的子宫内膜和培养的d4子宫内膜为样品，应用免疫组织化学、 western - blot等方法，检测了小鼠胚胎植入前后子宫内膜erk1 / erk2的表达部位及水平；用rt - pcr方法检测了egf及其受体egfr的表达情况；对培养的d4子宫内膜以le ~ y寡糖抗体阻断，观察了其对活性型mapk表达的影响。
Most of mapk upstream molecules are the molecular marker of the receptivity of endometrium during implantation period , for instance , evidence suggests egf and its receptor egfr may play a role in rendering the endometrium receptive to embryo implantation . the temporal and spatial expression of ley oligosaccharide in the uterus suggests that this factor may be involved in cell - cell communication between the uterus and blastocyst during implantation period 在植入期的子宫内膜， mapks的上游信号分子大多是其接受态的标志分子，如egf及其受体egfr ，可作为胚泡与子宫内膜间的信息传递物质，代替雌激素促进子宫上皮细胞分化、增生，诱导胚胎着床。
However , there are limitied documents about receptor signal transduction within uterine endometrium during implantation . the factors regulating endometrial receptivity remain poorly understood . the objective of this dessert is to investigate mapk ' s expression and location in differnt days of pregnancy , as more important , we try to elucidate the relation of mapk and the receptivity of endometrium 本课题组经研究还发现lewis ~ y寡糖在植入中呈阶段特异性表达，可影响其他如lif 、 egf 、 fn (纤连蛋白)和mmps (基质金属蛋白酶)等因子的表达，推测其可能作为一种信息分子经某种转导途径(例如mapk )而发挥作用。
