Cd226 , also named platelet and t cell activation antigen 1 ( ptal ) , was discovered by burns in 1985 . pta1 mainly expressed on activated t cell , nk cell , megakaryocyte and platelet . previous study indicated that il - 2 , tnf - a and pma could upregulate the expression of pta1 on t lymphocytes and tgf - p down - regulate its expression Cd226又称为血小板和t细胞活化抗原1 ( plateletandtcellactivationantigen1 , pta1 ) ，最早在1985年由bums等发现，主要表达于活化t细胞、 nk细胞、巨核及血小板谱系，参与t细胞的活化与分化以及血小板的活化和聚集。
Both spla 2 and ceramidehave been shown to inhibit bradykinin - , and pma - induced phospholipase d activation . these results indicated the existence of a subtle intertwined regulatory interaction between intracellular phosphoglycerol lipids and sphingolipids signaling pathways . in addition , we also found that spla can 2 down regulate theepidermal growth factor ( egf ) receptor activation 此外，我们还发现分泌型磷脂酶a能下调表皮生长因子受体的活化，它能明显的抑制表皮生长因子诱导2的受体自身磷酸化，并抑制表皮生长因子诱导的磷脂酶d活性和磷脂酶c - g的1酪氨酸磷酸化。
