Selkoe , d . j . , and d . schenk . " alzheimer ' s disease : molecular understanding predicts amyloid - based therapeutics . " annu rev pharmacol toxicol . 43 ( 2003 ) : 545 - 84 阿兹海莫症：以分子生物学领域的了解预测以类淀粉胜肽为基础的治疗《药理学与毒物学研究回顾杂志》 43 ( 2003 ) : 545 - 84
For the past decade there has been a lot of work on drugs called secretase inhibitors , which alter the activity of the enzymes that create amyloid beta - peptide 42 在过去的10年里人们对被称为分泌酶抑制剂的药物进行了大量研究，这种药物可以改变酶类产生淀粉样贝塔-肽42的活动。
Instead of producing amyloid beta - peptide 42 ( so called because it has 42 of the amino - acid units of which proteins are composed ) , they make peptides 37 or 38 amino acids long 与产生淀粉样贝塔-肽42 （因为它是由42个氨基酸组成而得名）所不同的是，它们产生了37或38氨基酸的肽段。
When stained with congo red and observed under polarized light , the amyloid has a characteristic " apple green " birefringence as seen here in a deposit around an artery in the heart 刚果红染色,在偏振光下观察,如图所见在心脏一动脉周围的沉积物,淀粉样物质呈现典型的“苹果绿”双折射光。
In alzheimer s disease , the commonest form , the brain atrophies and abnormal proteins , called amyloid , accumlate in the brain substance , in the form of senile plaques 阿氏痴呆症的病变，是大脑的萎缩，大脑组织出现了不正常的淀粉样蛋白，称老年斑，或神经细胞结构产生变化，称神经纤维缠结。
Noninvasive methods of detecting these abnormal proteins are potentially useful in developing markers for drug development aimed at blocking amyloid build - up and for diagnostics , the researchers added 另外，检测此种异常蛋白的非损伤型手段在开发阻止淀粉样蛋白形成药物的标记物上以及在诊断学上都具有潜在的重大意义。
Lewy body disease that is quite common in the west , is not commonly encountered . in alzheimer s disease brains in chinese , amyloid deposition predominantes whereas neurofibrillary tangles are less frequently seen 在病种方面，以阿氏痴呆症为主，约占23 ，脑血管性痴呆占13 ；而在西方很常见的路易体痴呆病则非常罕见。
During the course of the research , one drug in particular was identified as effectie in blocking the accumulation of beta - amyloid in the brain and preenting the deterioration of cognitie performance 在研究的过程中，特别筛选出一个能有效阻止脑内-淀粉样蛋白蓄积并且预防认知能力减退的药物，即盐酸普萘洛尔（心得安） 。
