The study on the relationship between the tumor - like proliferation of synoviocytes and the expression of c - myc and odc genes in adjuvant arthritis rats 类风湿关节炎大鼠滑膜细胞的类肿瘤样增生与相关基因表达的关系
1 . with testicular development , the products of c - myc translocate from the cytoplasm of spermatogonia to nuclei of spermatogonia 随着精子发育时期的不同， cngc产物在山溪蜕精巢中有从生殖细胞的胞质向胞核中转移的趋势。
Thompson cb , challoner pb , neiman pe , et al . levels of c - myc oncogene mrna are in variant throughout the cell cycle . nature , 1s985 , 314 : 363 赵书芳，金岩，赵皿，等.程序性细胞死亡在牙齿发育中的作用.牙体牙髓牙周病学杂志， 1999 ， 9 ( 1 ) ： 58
In the signal transduction system , c - kit is in the upstream as the stem cell factor ( scf ) receptor , while c - myc in the downstream as a target protein 在信号转导系统中， kit是干细胞因子( steelcellfactor , scf )的膜上受体，位于信号级联的上游，而myc处于下游。
The first member be found ofndrg gene family is ndrgl , which was isolated as a new gene upregulated in n - myc mutant mouse embryos and ft is repressed by n - myc and c - myc Ndrg基因家族中最早被发现的是ndrg1 ，它是在研究n - myc下游调节基因时从小鼠胚胎中发现的一种新基因。
4 . in the absence of tgf - 1 , overexpression of the ha - axud1 fusion protein decreased the expression of bax and resulted in a marked down - regulation of p53 protein expression . by contrast , it increased the expression of c - myc 在无tgf一pl刺激下， ha一axudi蛋白的过表达与对照质粒转染的细胞相比，能降低bax的表达并显著下调p53蛋白的表达，相反，却增加c一mye蛋白的表达。
It can be concluded from the results that c - myc plays an important role in regulatin g the related genes in meiosis of spermatomeres and spermiogenesis and in regulating the secretion of the secretory cells in the spermatheca 从实验结果看， myc蛋白可能在减数分裂中激活相关基因，尤其是在精细胞形成早期可能参与了精细胞内大量的基因转录，还可能参与了受精囊囊壁上皮细胞的分泌活动。
On the other hand , in the presence of tgf - 1 , the expression level of bel - xl and c - myc were decreased and the expression of bax was increased in hepg2 cells transfected with pcdnas . 1 / ha - axudl plasmid , whereas no change of caspase - 3 and p53 occurred 另一方面，在tgf一pl刺激下， ha一axudi蛋白过表达细胞组中bcl一xl和c一myc蛋白的表达却下降，而bax蛋白表达反而增加， caspase一3和p53的水平没有改变。
At last , the related proteins and genes in meiosis are activated through a series of signal proteins , c - myc is maybe one of the target proteins in the c - kit / scf signal transduction system . it activates or suppresses the target genes in forms of myc - max , myc - myc , max - max , max - mad or max - mxil Myc蛋白可能作为c - kit / scf信号转导系统的靶蛋白之一，以同源二聚体与max或mxil形成异源二聚体作用于靶基因的特有序列，激活或抑制靶基因的转录活性。
To get in vivo evidences that apoplast calmodulin con 1d regulate plant growth and development process , a chimeric secretion form of calmodulin binding peptide , which contains a signal peptide , a calmodulin binding domain and a c - myc epitope was constructed . the chimeric gene was introduced into arabidopsis . it was expected that the overexpression of this chimeric protein could be secreted into cell wall and bound to apoplast calmodulin , which could reduce the apoplast calmoduin concentration to make an apoplast camodulin " antisense " plant . by observing the potential phenotype change of apoplast calmodulin " antisense " plant , the in vivo function of apoplast calmodulin on plant growth and developmental process could be speculated 但这些多是采用生理学手段和药理学方法而得出的体外( invitro )实验结果，为了取得质外体cam在植物生长发育过程中发挥重要作用的invivo实验证据，根据动物中的一些研究方法，本实验设计并构建了带有信号肽、 cam结合肽( can小肽) 、 epitope ( c - myc )融合基因的载体，并将融合基因通过真空渗入法转入拟南芥，预期过表达的融合蛋白将会被分泌到细胞外并与质外体cam相结合，这样就会抑制质外体cam的功能，从而可以构建质外体cam的“反义”植株，通过观察质外体cam “反义植株”的表型改变，就可以推断质外体cam在植物生长发育过程中的功能。
