The npr - c is a membrane - bound receptor that lacks the intracellular guanylate cyclase domains of the biologically active receptors and is therefore uncoupled with cgmp . npr - c functions as a clearance receptor by binding with and internalizing natriuretic peptides . nprs are widely and differently distributed in most tissues and can be up - or down - regulated in many pathological processes , which indicates that they have different effects on different tissue and participate in the regulation of their physiological and pathological process 正常情况下，三种受体在体内均广泛分布，但在不同组织中的分布有很大差异，而且在不同病理条件下钠尿肽受体数目还可发生上调和下调，提示钠尿肽家族及其受体对不同组织器官的作用不同，并参与它们的生理和病理过程的调节。
