These anthraquinones are extremely cytotoxic ( they fight against ) towards a broad spectrum of bacteria , fungi , and viruses that include pneumonia , e coli , blood infections , diarrhea , skin infections and ( tuberculosis 蒽醌是一种极为有效的广谱类抗细胞毒素物质，可抗击多种细菌、真菌、病毒，包括导致肺炎的细菌和病毒、大肠埃希氏杆菌，以及导致血液感染、腹泻、皮肤感染和肺结核的微生物。
Honokiol , as a major active constituent extracted from the bark of magnolia officianlis , can inhibit tumor growth through cytotoxic activity , inducing differentiation and apoptosis , inhibiting vessles , synthesis of enzyme , dna , rna and ( or ) protein 和厚朴酚作为木兰科植物厚朴的主要活性成分，通过细胞毒作用，抑制新生血管，诱导细胞分化，诱导细胞凋亡，抑制酶的合成以及抑制dna ， rna和（或）蛋白质的合成等机制发挥了抗肿瘤的作用。
Increasing local control and sur - vival after definite chemoradiation seems possible not only by using optimized radiation fractionation schedules and escalated total doses , but also by associating more convenient and less toxic chemotherapy agents at the right cytotoxic or radio - sensitizing dose 明确的放化疗后无论是选用优化放疗加大总剂量，还是在细胞毒素或敏感放疗剂量中加用方便并且毒性小的化疗药物，似乎都能提高局部控制和生存期。
In the light of established surgical techniques and higher efficacy of modern radiotherapy , cytotoxic and hormonal drugs in breast cancer , a population survey by the faculty of medicine of cuhk revealed the public still have many misconceptions over breast cancer management and knowledge of mmg is not enough 尽管外科技术日趋成熟，现代放射疗法及乳癌的细胞毒素和激素药物的效能提高，中文大学医学院肿瘤学系的杨明明教授、关永康教授和徐仲
Hi our study , dendritic cells ( dcs ) were derived from the cultivation of peripheral blood monocytes in vitro successfully . then to observe whether dcs transfected with carcinoembryonic antigen ( cea ) - vaccinia recombinant virus ( rv - cea ) can induces cytotoxic t lymphocyte - mediated cea - specific immunity in vitro 体外成功地完成了cd14 +单核细胞来源的树突状细胞( dc )的培养，并进一步研究人癌胚抗原重组痘苗病毒( rv - cea )转染dc后体外诱导的cea特异性细胞免疫。
T cell will be apopotosis , clone depletion and / or anergy , in turn inducing an antigen - specific tolerance . ctla4 ( cytotoxic t lymphocyte associated antigen 4 ) , a prominent negative costimulator , can competitively bind with b7 , and block b7 - cd28 pathway and t cell activation by producing inhibitory singals Ctla4 ( cytotoxictlymphocyteassociatedantigen4 )作为一种主要的共刺激负调节剂，可竞争性结合b7分子，阻断b7 - cd28途径、并通过产生抑制性信号使t细胞活化障碍。
Porcine il - 12 ( pil - 12 ) , also termed as natural killer cell stimulatory factor ( nksf ) and cytotoxic lymphocyte maturation factor ( clmf ) , can induce some cytokines , particularly ifn - , from t and nk cells , as well as enhance the cytotoxic activity of these cells . its most critical role may be to initiate the development of cell - mediated immunity by promoting the differentiation of th1 cells from naive t cells 白细胞介素- 12 （ il - 12 ）又名nk细胞刺激因子（ nksf ）或细胞毒淋巴细胞成熟因子（ clmf ） ，能诱导t细胞和nk细胞产生ifn - ，并增强其细胞毒活性，它的关键作用是能诱导th0细胞分化为th1细胞以激发细胞免疫进程。
Conclusion : dendritic cells ( dcs ) can be derived from peripheral blood monocytes in vitro successfully treated with rhgm - csf of 1000 u / ml plus il - 4 of 500 u / ml . second , dcs from the patients of advanced carcinoma of large intestine were transfected with rv - cea , and then cocultured with autologous t cells . the cytotoxic activity against cea - secreting tumor cells were assessed and compared with those of t cells induced by dcs without rv - cea transfection 其次，用rv - cea转染晚期大肠癌患者的dc ，再激发自体t细胞，然后检测t细胞对cea分泌性肿瘤细胞的体外杀伤活性，并与未经rv - cea转染的dc激发的t细胞及野生型痘苗病毒转染的dc激发的t细胞进行对比。
Of particular interest are " memory cytotoxic t cells " , because people infected with certain viruses , especially cytomegalovirus ( which most of us have , in fact ) , accumulate a huge number of this type of immune cell that is specifically reactive against proteins encoded by that virus 特别有趣的是"记忆细胞毒t细胞" ，因为被某些病毒感染的人，特别是被细胞巨化病毒感染的人（实际上我们大部分人都被它感染） ，大量积累特异地起反应来抗击该病毒编码的蛋白质的此类免疫细胞。
Cea gene was transferred into human dcs , and specific anti - cancer effecs induced by the vaccine was observed . this test is part of my tutor ' s . hang you - tian has observed the induction of crcinembryonic antigen ( cea ) - specific cytotoxic t - lymphocyte responses in vitro when he transfected dcs with pcdna3 - cea , and has observed the immunity effects of the dcs ( pcea ) inoculateing against to ct 26 ( hcea + ) loaded in balb / c mice . after vaccination with the cea gene - modified dc , the survival time of the mice vaccinated with ct26 + ( cea + ) ws prolonged more potently than that of the mice vaccinatd with other dcs 癌胚抗原( carcinoebryonicantigen , cea )是一种研厂郑州大学2002年硕士毕业论文转染人癌胚抗原真核表达质粒的人树突状细胞的抗瘤作用究最为深入的肿瘤相关抗原（ tumorassociatiednigen ， taa ） ，在90的胃肠道肿瘤、 50的乳腺癌及70的非小细胞肺癌中有高水平的表达，是目前国际上公认的肿瘤标志物。
