New york ( reuters health ) jan 17 - increasing the planned dose intensity of cisplatin and doxorubicin for osteosarcoma may improe the histologic response , but it does not increase progression - free or oerall surial , new research suggests 据1月17日路透社健康新闻报道，新的研究成果显示，增加骨肉瘤患者应用顺铂和阿霉素的常规化疗计量，虽然可以改善组织学反应，但并不能控制疾病发展或提高总生存率。
The histologic lesions were characterized by the remarkable atrophy of intestinal villi , basal vacuolation of enterocytes , increment of the crypt and the villus - to - crypt ratio had significantly decrease . compared with that of noninoculated control chicks . besides . intestinal villi become thin and flat . or cubic , also accompanied with necrosis . many villous enterocytes were detached from the lamina propria and the lamina propria contained a diffuse infiltrate of lymphocytes , plasma cells , macrophages . the characteristic ultrastructural changes observed by electronmicroscope were swelled mitochondria and dilated endo - plasticreticulum . ribosome on the surface of endo - plasticreticulum fall off and the number of ribosome within the cell decrease 动物回归试验中接种两周龄spf鸡， 24h后陆续发病，表现为持续性水样腹泻；剖检可见病鸡脱水、小肠内有大量的液体和气泡、肠粘膜变薄；组织学变化为肠绒毛上皮坏死、脱落，绒毛平均长度减少而隐窝深度增加，固有层中淋巴细胞浸润。其临床症状及病理组织学变化与自然发病相同。
There are some different in the terminology of " malignant ameloblastoma " and " ameloblastic carcinoma " ; " malignant ameloblastoma " refers to a neoplasm in which typical histologic features of ameloblastoma are seen in the primary tumour located in the jaw as well as in any associated metastatic deposits , and " ameloblastic carcinoma " described as ameloblastomas in which there had been histologic malignant transformation 在定义上恶性造釉细胞瘤与造釉细胞癌有所不同，前者用以描述具有远端转移情形但组织学上为典型的造釉细胞瘤，而后者为组织学上发生恶性转变之造釉细胞瘤。
The quality of feeder layer is affected by a lot of factors , such as animal breed , culture medium , passages in vitro and experiment condition , etc . as to the production of feeder layer , there are a few reports about morphological and histologic change when of embryonic body fibroblast when culturing in vitro and cryopreservation , so kunming mouse were chosen as experimental animals and morphological and histologic changes were studied in course of its embryonic body culturing . we expect to offer theoretical foundation to our laboratory for setting up feeder layer storehouse . at the same time , the feasibility of myocardium tissue culturing with fibroblast layer altogether was studied so that established foundation for studied the biological characteristic of heart outside body 小鼠胚体成纤维细胞的培养是制备饲养层的重要途径，其制备、传代及冷冻保存均有不同的研究报道，饲养层的质量受许多因素的影响，如动物的品种、培养液、所传代数及实验条件等，关于饲养层制备过程中的胚体细胞培养、传代、冷冻后的细胞形态、组织学等方面的研究报道很少，故本实验以昆明小白鼠为实验动物，研究其胚体培养过程中细胞的形态学、组织学等方面的变化，以期为本实验室建立饲养层细胞库提供理论依据，同时探讨心肌细胞和成纤维细胞层共培养的可行性，以期为心脏生物学特性的体外研究奠定基础。
