Amyloid plaques form when a molecule called amyloid precursor protein ( app ) is chopped up by two enzymes known as beta - secretase and gamma - secretase 当一种叫淀粉样前体蛋白（ app ）的分子被两种酶? ?分别叫作贝塔-分泌酶和伽玛-分泌酶? ?切断时就形成了淀粉样斑块。
Indeed , investigators already know the three - dimensional structure of beta - secretase and have used it as a guide for computer - based drug design of potential inhibitors 的确也是，研究人员已经知道了分泌酶的立体构造，并以此为师，利用电脑设计出可能的抑制剂。
For the past decade there has been a lot of work on drugs called secretase inhibitors , which alter the activity of the enzymes that create amyloid beta - peptide 42 在过去的10年里人们对被称为分泌酶抑制剂的药物进行了大量研究，这种药物可以改变酶类产生淀粉样贝塔-肽42的活动。
Today gamma - secretase is recognized as a founding member of a new class of proteases that apparently wield water within cellular membranes to accomplish their biochemical tasks 我们现在知道，分泌酶是某类新蛋白酶中最早被发现的，这群蛋白酶显然利用细胞膜里的水来完成生化任务。
The protease plays a key role in the generation of - amoyoid peptide which is a central event in the pathogensis of ad and its inhibiting is proved to be great beneficial to ad treatment 抑制-分泌酶的活性能从上游控制关键致病因素-淀粉样多肤的生成，从而达到治疗老年痴呆症的目的。
Because beta - secretase clearly falls into this family , researchers were able to exploit the vast knowledge about these proteases , leading to a very detailed understanding of this enzyme and how it might be shut down 因为分泌酶显然是这个家族的成员，研究人员可以善用他们对这个家族的丰富知识，深入理解这个酵素的功能，以及可能的抑制方法等。
Subsequently , we and others showed that the inhibitors of gamma - secretase bind directly to presenilin and that three other membrane - embedded proteins must assemble with presenilin to allow it to catalyze 我们与其他人后续的研究指出，分泌酶的抑制剂会直接结合到早衰素上，而其他三种嵌在膜里头的蛋白也必须与早衰素组合在一起，才能执行切割任务。
Second , my laboratory , then at the university of tennessee at memphis , discovered that compounds in the same chemical category as the classical inhibitors of aspartyl proteases could block gamma - secretase cleavage of app in cells 其次，我在美国田纳西州大学曼菲斯分校时，我们实验室发现，与天冬胺酸蛋白酶传统抑制剂同类的化合物，可以阻止细胞内分泌酶切割app的反应。
Genetic studies suggest that blocking the enzyme ' s activity will not lead to harmful side effects ; deletion of the gene encoding beta - secretase in mice eliminated a - beta formation in the rodents ' brains without causing any apparent negative consequences 遗传研究的结果暗示，阻断这个酵素的活性，并不会造成有害的副作用；移除小鼠的分泌酶基因，小鼠的脑部就无法制造出a - ，但却不会造成任何明显的负面后果。
This concern , recognized by a 10 - year - old , is very real : the potential of gamma - secretase as a therapeutic target is tempered by the fact that this enzyme plays a critical role in the maturation of undifferentiated precursor cells in various parts of the body , such as the stem cells in bone marrow that develop into red blood cells and lymphocytes 这个连10岁小孩都注意到的顾虑，是再实际不过的事了：虽然分泌酶可能是个治疗标的，但我们却不能不注意一个事实：这个酵素对身体各处未分化的前驱细胞（像是可分化成红血球与白血球骨髓干细胞）的成熟，扮演著关键角色。
