Results gutongling ointment ( 40 % and80 % , local use for three days ) had significant inhibitory action on auris swell induced by dimethylbenzene in mice , foot swell induced by egg white and carageen glue , gasbag swell induced by croton oil and penetration of capillary vessel in rats 结果：骨痛灵软膏中、大剂量对小鼠二甲苯性耳肿胀，大鼠蛋清和脚叉菜胶性足跖肿、巴豆油气囊肿及组胺所致毛细血管通透性的增加均有明显抑制作用。
Methods : the methods of the increase of blood capillary permeability of the abdominal in mice induced by injection of acetic acid and the swelling of the ear in mice caused by crotin were used for anti - inflammatory experiments , aspirin and hydrocortison were respectively used as the positive control ; the methods of abdominal pain in mice induced by acetic acid and woolfe - macdonald were used for analgesic experiments , morphine hydrochloride as the positive control 方法：小鼠随机分组，抗炎实验用醋酸诱发小鼠腹腔毛细血管通透性增高和用巴豆油诱发小鼠耳肿胀，阳性对照分别为阿斯匹林组和氢化可的松组；镇痛实验采用醋酸诱发小鼠腹痛和用热板诱发小鼠足痛，阳性对照为盐酸吗啡组。
Abstract : several - aromaticamino ketones , which were designed according to some hypothetical models of the cyclooxygenase and 5 - lipoxygenase active sites , were synthesized by an amino exchange reaction . the structures of the eight new compounds were confirmed by ir , 1h - nmr and elemental analysis . the results of the pharmacological tests showed some of the investigated compounds had significant anti - inflammatory activity on croton oil - induced ear edema of mice 文摘:根据环氧化酶、 5 -脂氧化酶活性中心结构模型设计了一组-芳胺酮类化合物，并用胺交换反应合成了这些化合物.经红外光谱、核磁共振氢谱及元素分析证实了8个未见文献报道的化合物的结构.药理实验结果显示.部分受试化合物在巴豆油诱发小鼠足趾肿胀模型中表现出一定的抗炎活性
