Results : ( 1 ) sequencing of katg from 101 inh - resistant strains showed point mutations , small deletions or insertions in 81 isolates ( 80 . 20 % ) , but no complete deletions were identified 结果( 1 ) 101株耐异烟肼结核分枝杆菌临床分离株中未发现katg基因完全缺失。共检测到80 . 20 ( 81 / 101 )的菌株存在点突变、小的缺失或插入。
Method : a total of 101 isoniazid - resistant and 43 susceptible strains of mycobacterium tuberculosis were analyzed by pcr and sequence analysis of their katg , inha , ahpc , kasa , oxyr genes 方法对144株结核分枝杆菌临床分离株( 101株异烟肼耐药株及43株异烟肼敏感株) katg ， inha ， ahpc ， kasa及oxyr基因进行pcr扩增及dna序列分析。
An ser - to - ala substitution at position 94 was detected in 2 isolates showing low level isoniazid resistant , an ile - to - thr substitution at posotion 21 was found in 2 isolates showing high level isoniazid resistant , and small deletion was identified in 1 isolates showing high level isoniazid resistant 94位氨基酸突变的2株细菌低度耐药， 21位氨基酸突变的2株细菌高度耐药，碱基缺失的细菌高度耐药。 43株异烟肼敏感株中没有检测到inha基因突变。
It possesses 160 workers and staff members among which there are 38 various talents from polytechnic schools , colleges and universities . this enterprise mainly manufactures simvastatin . rifampicin , rifamdin , isoniazid , pyrazinamide , ethambutol , ivermectin etc pharmaceutical intermediates and raw material medicines 本企业主要生产头孢拉定、头孢氨苄、辛伐他汀、利福平、利福定、异烟肼、异烟酸、吡嗪酰胺、乙胺丁醇、依维菌素、等医药中间体和原料药。
Be based on the reason of above , at tuberculosis the young men and women of mobile period shoulds not be marry live together , at present the many specific that fight consumptive disease is like streptomycin , isoniazid , acerbity to ammoniac willow natrium , rifampin to wait , can make much new come on the patient passes a year of to a year of half cure heal , its recrudesce rate is very low also 基于以上的原因，处在肺结核活动期的男女青年不宜结婚同居,目前有大量的抗痨特效药如链霉素、异烟肼、对氨柳酸钠、利福平等，可使大部分新发病患者经过一年到一年半治疗而痊愈，其复发率也很低。
Objective : to elucidate the characterization of katg , inha , ahpc , kasa , and oxyr gene mutations in isoniazid - resistant clinical isolates of mycobacterium tuberculosis , and discuss the value of judging the susceptibility of mycobacterium tuberculosis strains to isoniazid by dna sequencing 目的阐明结核分枝杆菌耐异烟肼临床分离株katg基因、 inha基因、 ahpc基因、 kasa基因及oxyr基因突变特点，探讨是否可能通过dna序列分析来判断结核分枝杆菌对异烟肼的敏感性。
The phase ii trial results of a gatifloxacin - containing regimen are demonstrating good potential . the regimen is significantly more potent than the currently recommended six - month regimen of isoniazid , rifampicin , pyrazinamide and ethambutol , and suggests that when gatifloxacin is used instead of ethambutol , the standard six - month regimen may be shortened to four months 这种治疗方案明显比目前建议的为期六个月的异烟肼、利福平、吡嗪酰胺和乙胺丁醇治疗方案更有效力，并表明如果用加替沙星代替乙胺丁醇，可将标准的六个月治疗方案缩短至四个月。
