Several studies have shown that so2 and its derivatives could induce chromosomal aberrations , sister chromatid exchanges and micronuclei in human blood lymphocyte , bone marrow cell in mice and chl 研究发现， so _ 2及其衍生物可引起人外周血淋巴细胞、小鼠骨髓细胞、中国仓鼠肺成纤维细胞等哺乳动物细胞的染色体畸变、姊妹染色单体交换及微核的形成。
There are not significant correlation between concentrations and mcn when two herbicides treat together . on the contrary , the frequencies of mcn of large of low concentration groups are higher than those of high concentration groups 除草剂的诱变浓度和微核细胞率之间未呈现出一定的正相关性，相反，大部分低浓度组的微核细胞率不同程度地高于高浓度组。
In four kinds of weedicides , the average frequencies of mcn in erythrocytes of loach induced by sofit have a obviously increase and significant different in comparison with other three herbicides , it indicates that sofit has greater mutagenic activity and toxicity than other three herbicides 扫?特对泥鳅红细胞微核的诱变效应最强，扫?特诱发的泥鳅红细胞微核细胞率与氟乐灵和2 -甲- 4氯钠水剂差异极显著，与精禾草克差异显著。
Results the mutagenicity of water body displayed a rule of well < river < pool ; the mutagenicity detected in dry season was higher than that in rainy season ; the numbers of micronucleus induced by river and pool water in dry season were found to be positively correlated with the incidence of stomach , esophagus and liver cancer , whereas only pool water showed significant relationship with stomach cancer occurrence in rainy season ; well , river and pool water in taixing city all can cause dna damage in peripheral blood lymphocytes , and water of river cause dna damage heavily 结果：水体致突变性呈塘水河水井水的规律；相同地区水体的致突变性在枯水期比丰水期强；枯水期河水和塘水诱发的微核效应与当地肝癌、胃癌和食管癌发病率有高度的正相关，而丰水期仅塘水微核效应与胃癌发病率有正相关；诱发微核率较高的井水、河水和沟塘水对人淋巴细胞都具有致突变性，其中尤以河水为甚。
In the second part , the influences of la on micronucleus rate were observed by using the rat marrow cell micronucleus test . and the cleavage action of la on genome dna were studied too . the results manifest that a certain concentration of la can increase micronucleus rate obviously and induce the cleavage action and structural change of genome dna (二)采用小鼠骨髓细胞微核检测技术研究了稀土元素镧对微核率的影响，同时采用体外培育技术和紫外分光光度法研究了镧对基因组dna的断裂作用，结果表明一定浓度的镧能引起微核率显著升高，并可导致基因组dna的断裂以及结构的改变。
It distributes widely and survives easily . smears of blood samples were prepared conveniently ; and there is no restriction on seasons . for these reasons , mcn and ona test in erythrocytes of loach is rather useful index for detecting mutagenetic compounds in the aquatic environment 研究结果表明，泥鳅对于核变异的诱发具有较高的敏感性，且泥鳅分布较广，易存活，且血量也较搬料多，并能在不同季节评测水质状况，因此，泥鳅红细胞微核和核异常测试法可作为监测水环境中致变化合物的一个较为实用的指标。
