Ie protein have multiple functions , such as conversion of the host cell into a metabolically activate states , activation of viral early genes in the early phase , repression of their own transcription . ie 180 proteins can stimulate transcription from both homologous such as the icp4 of hsv ( herpes simplex virus ) and heterologous viral and cellular promoter such as - globe protein 经分析伪狂犬病病毒立即早期蛋白( immediate - earlyprotein180 , ie180 )的蛋白质结构，发现ie180具有转录激活因子的结构特征，能与类rna聚合酶结合， ie180基因缺失突变体对sv40及cmv启动子调控作用的研究，是考察ie180能否作为转录激活因子应用的关键。
