Changes in p - catenin expression or localization were found in cancer cells and tumor tissues , it had been reported that p - catenin translocated from membrane at the normal condition into the cytosol or nucleus in cancer cells . recently , p - catenin has been referred to an oncogene 研究发现，癌变的细胞中-连环蛋白的分布发生了异常，由胞膜转移到胞浆和胞核，因此，已把-连环蛋白归为一个新的癌基因。
The oncoprotein v - src is similar to c - src , and most functions of them is sameness , while some difference is important . v - src can infection mammalian cell and leads to neoplastic transformation of cell , however , c - src could n ' t . in vitro , v - src is activity and c - src is inactive 而病毒中的v - src蛋白与c - src结构十分类似，大致的功能也相同，但v - src具有转化正常细胞的功能，使之癌变，而c - src则无此作用。
To researchers , this association between cancer and prematurely short telomeres raises the possibility of one day using telomere length as a biomarker of cancer or an early warning system that can alert physicians to pre - symptomatic cancerous changes that are underway 对研究者来说，这种癌症与端粒酶提前变短之间的联系使今后以端粒酶的长度作为癌症的生物标记成为可能，也为今后医生对早期无症状的癌变提供了警告信息。
Abstract : selective mechanisms exist in organism and biosphere , which select the cells with less dna injuy and reproduces them . there are two models ; mechanisms 1 and mechanisms 2 , represented respectively b bacteria and mechanolytes of human beings . cells with mechanisms 1 ( e . g . bacteria , generative cells , cancer cells ) can reproduce infinitely , while somatic cells can not . there are deep - going reasons behind the two categories of selective mechanisms . the canceration of the cells is a degenerating process from mechanisms 2 to mechanisms 1 摘要生物界存在一类筛选机制,它将dna损伤较小的细胞筛选出来,产生后代.主要有两类模式机制1和机制2 ,分别以细菌和人的成纤维细胞为代表,那些具有筛选机制1的细胞(如:细菌、生殖细胞、癌细胞)能无限传代,而体细胞则不能.这两类筛选机制背后有更深刻的原因,而细胞的癌变正是从机制2退化为机制1的过程。
Exposure to genistein , an estrogen , before puberty causes mammary gland differentiation . " a differentiated cell undergoes less proliferation and therefore is less likely to progress through the cancer process , " he said . " howeer , if the estrogen is administered to an animal after the deelopment of an estrogen - responsie tumor , the growth of this tumor will be stimulated , " he said 青春期前服用雌激素染料木素可导致乳腺分化， “分化的细胞很少增殖，因而很少发生癌变；然而，如果已经患有雌激素反应肿瘤的动物服用雌激素，则刺激肿瘤的生长。 ”
Optical tomography of biological tissue has become an active research field because of the advantages of noninvasive , sensitive and functional imaging for biomedical diagnosis . it is very helpful to find cancerous tumor of parenchyma organs in the initial stage , but the biological tissue is optically turbid and a strong scattering media , which results in a limited penetration depth of several millimeters with high resolution 光学相干层析技术，作为一种新型的无损医学成像检测方法，其探测精度高，而且有可能实现功能成像，对于癌变组织的早期发现和诊断具有重要的意义，但受目前技术的局限性，还不能完全满足临床应用的要求。
Cdk2 is an important member in cdks family , it directly participates regulation of g ^ s checkpoint and dna replication in s phase , its activity and functional regulation is one of the crucial key in cell cycle ' s operation , otherwise ; cdk2 has very close relation with cell canceration Cdk2是cdk家族中的重要成员，它直接参与细胞周期g _ 1 / s限制点( checkpoint )和s期dna复制的调节，它的活性和功能调节是细胞周期运转的关键环节之一，与细胞癌变有着十分密切的关系。
In this article , we microinjected camp ( as activator of pka ) and protein kinase inhibitor ( pki ) ( as inhibitor of pka ) into mouse 1 - cell stage fertilized eggs , the camp concentration , pka and mpf activaty were detected , also the cdc25c , cdc2 phosphorylated state and the concentration of ptyr15 for cdc2 , cyclin b1 . materials females of 4 - 5 week - old kuming mice and males of 8 week - old kuming mice were supplied from the department of laboratory animals , china medical university 本实验应用pka激动剂camp及抑制剂pki显微注射入小鼠二一细胞期受精卵并观察卵细胞m期形态学变化及pka对mpf活性的影响以及cdc25c ， cdcz电泳迁移率， cdcz的磷酸酪氨酸ptyrl及周期素b含量，为揭示pka在哺乳动物细胞周期调控机制，对生长、发育、癌变、死亡的研究提供理论依据。
Structure and function of enzymes ; kinetics of enzyme action , inhibition , inactivation and activation ; regulation mechanism of enzymatic activity ; exploitation and applications of enzymes and inhibitors ; folding and unfolding of proteins ; anticancer polypeptide ; canceration mechanism ; proteomics 酶的结构与功能、酶作用动力学、抑制动力学、失活动力学、激活动力学、酶活力调控机理、抑制作用机理；酶产品及酶抑制剂的开发应用；蛋白质折叠与去折叠；抗癌多肽；癌变机理；蛋白质组学
