Studies on the regulations of steroids , receptors and proto - oncogenes during the follicle development , and studies on these multual relations , have great significance in the study on the mechanism of the oocyte development 性类固醇激素及其受体、原癌基因在卵泡发育周期中的作用、以及三者之间相互关系的研究，在卵子发育机制的研究中具有重要的意义。
Occurrence of liver carcinoma is a synergistic action by multiple factors which include virus infection , carcinogen , oncogene activation , anti - oncogene inactivation , liver cell apoptosis , failure of proliferation regulation and so on 肝癌的发生是一个多因素协同作用的过程，这个过程中包括病毒感染、致癌物的作用、癌基因的激活和抑癌基因的失活、肝细胞的凋亡和增殖调节失控等多因素多环节。
Changes in p - catenin expression or localization were found in cancer cells and tumor tissues , it had been reported that p - catenin translocated from membrane at the normal condition into the cytosol or nucleus in cancer cells . recently , p - catenin has been referred to an oncogene 研究发现，癌变的细胞中-连环蛋白的分布发生了异常，由胞膜转移到胞浆和胞核，因此，已把-连环蛋白归为一个新的癌基因。
Recent research includes molecular mechanism of microcirculatory disturbance and its experimental therapy , influence of tnf alpha on endothelial cell injury and oncogene expression , therapeutic effects of lingzhi on microcirculation disturbance and circulatory endothelial cell 多年来主要从事微循环障碍的分子机制及实验治疗研究，曾参加tnf对内皮细胞损伤及癌基因表达的变化、中药灵芝改善微循环及循环内皮细胞的研究。
Doc - 1r gene is an candidate tumor suppressor gene which was discovered by zhangxue . it can interact with cdk2 specifically and restrain cdk2 transportation into the nucleus , which will block the formation of cdk2 and cyclin complex and hinder the process of cell cycle Doc - 1r基因是张学等发现的一个候选抑癌基因，它可与cdk2特异性结合，抑制cdk2的入核转运，使cdk2不能与cyclin形成复合物，从而阻抑细胞周期的进程。
A featured paper in the february 14 issue of nature cancer gene therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors , based upon a fundamental new understanding of the differences between cancerous and normal liver cells 2月14日发行的自然癌基因治疗杂志的头版文章通过对肝癌细胞和正常肝细胞的比较表明肝脏的癌细胞是使用病毒载体进行癌基因治疗的理想靶点。
One approach is to find tumour - associated and microenvironment - associated oncoantigens required for progression from one tumour stage to the next by comparing gene signatures isolated from the different stages of tumour progression in cancer - prone transgenic mice 一种方法就是去寻找肿瘤相关及微环境相关的癌基因，而这些癌基因则是通过比较患瘤倾向的转基因小鼠的肿瘤进展不同阶段分离出来的基因信号而来发现从肿瘤发展的一个阶段到下一个阶段所必需的基因。
Curcumin has been shown to induce a wide variety of tumor cells by several mechanisms , mainly including modulation of the expression of oncogenes and cancer suppressor genes , down - regulation the activation of transcription factors , via many signal transduction pathways , and the modulation of cell cycle . provides an overview of domestic and international apoptosis mechanisms of malign tumor cells induced by curcumin in order to better explore and open up new avenues of cancer treatment 姜黄素能够诱导多种肿瘤细胞系凋亡,其机制主要是调控癌基因和抑癌基因,下调多个转录因子活性,通过多种信号转导途径,诱发细胞周期停滞而诱导细胞凋亡.对近年来姜黄素诱导细胞凋亡的机制进行综述,以便更好地探求和开辟治疗恶性肿瘤的新途径。
Rapl belongs to ras superfamily of small gtp - binding proteins , which is considered to control cell growth , differentiation and survival . rapl was regarded as an antagonist of ras because it can revert the phenotype of oncogene ras transformed cells . recent researches show that rapl has its ras - independent functions in a variety of cellular systems besides its effect as an antagonist of ras Rap1除具有逆转原癌基因ras激活突变体所导致的细胞形态改变而被认为是ras的拮抗物外，最近的研究还发现rap1在一系列的细胞系统中有独立于ras之外的功能，如控制与细胞粘附有关的事件等，因而成为研究的热点。
In recent years , studies indicated these molecular markers mainly involved : oncogenes and tumor - suppressor genes mutate or rearrange in some thyroid neoplasms ; the exceptional increasing on the activity of telomerase ; the special proteins which are related to cell cycle regulation or adhesion express excessively ; as well as some special matter which is discovered recently 近年研究表明这些分子标志物主要涉及癌基因或抑癌基因的突变或重排；端粒酶活性的异常增高；一些与细胞周期调控或与粘附有关的特殊蛋白的表达；以及一些新发现的特异物质。
