Relationship between serum angiotension - converting enzyme activity and plasma plasminogen activator inhibitor activity in patients with myocardial infarction 心肌梗死患者血清血管紧张素转换酶与血浆纤溶酶原激活剂抑制物1的活性及其相关性
The relativity of the activity change of tissue - type plasminogen activator and type 1 plasminogen activator inhibitor in patients with cerebral infarction and defect of nerve function 脑梗死患者血浆组织型纤溶酶原激活物和纤溶酶原激活物抑制物活性的变化与神经功能缺损的相关性
Several factors which influence the production of douchi fibrinolytic enzyme were analyzed , including amount of soaking water , soaking time , crash degree of soybean , carbon source , ionic strength and cooking time 分析了影响豆豉纤溶酶产量的诸多因素，包括大豆浸泡水量、时间、大豆破碎程度、碳源、离子强度、蒸煮时间等。
Tissue - type plasminogn activator ( t - pa ) is a kind of high efficient and specific thrombolytic medicine and is used widely to cure blood vessel embolism diseases . at present , t - pa has been expressed in e . coli 组织型纤溶酶原激活剂( tissue - typeplasminogenactivator , t - pa )是一种高效特异的溶血栓药物，被广泛地应用于血管栓塞性疾病的治疗。
Angiostatin ( as ) is a kind of polypeptide identified as a product of plasminogen cleavaged by protease . it blocks neovascularization by directly inhibiting endothelial cell proliferation and migration 血管抑素( angiostatin ， as )是血浆纤溶酶原( plasminogen ， plg )经蛋白水解酶降解生成的多肽片段，是直接作用于血管内皮细胞的血管生成抑制剂。
Objective , clone tissue - type plasminogen activator ( t - pa ) gene and construct a new kind of recombinant vector containing human tissue - type plasminogon activator ( t - pa ) cnda neither cytotoxiaty nor actovating prot - oncogenes 目的：克隆组织纤溶酶原激活物( t - pa )基因并构建一种无细胞毒性、不激活原癌基因的真核表达的pcdna3 . 1 ( + ) / t - pa质粒载体。
Angiostatin , a multiple kringle ( 1 - 4 ) - containing fragment of plasminogen , is an effective natural inhibitor of tumor angiogenesis , which is a potent inhibitor of angiogenesis in vivo , and selectively inhibits endothelial cell proliferation and migration in vitro 血管抑素angiostatin是纤溶酶原的内源片段，包括四个kringle结构，是一种重要的内源性新生血管生成抑制剂。
The first 24 amino acid residues of the n - terminal sequence of ba - dfe were aqsvpygvsqikapalhsqgftgs , which is different from those fibrinolytic enzymes , such as nk ( nattokinase ) , ck ( a fibrinolytic enzyme from chungkook - jang ) and kk ( katsuwokinase ) Ba - dfe能直接降解纤维蛋白，不能激活纤溶酶原形成纤溶酶。蛋白质测序结果显示，该酶n -端24个氨基酸序列为aqsvpygvsqikapalhsqgftgs 。
The cdna sequence with 789 bp encodes an uncompleted open reading frame ( orf ) of 263 amino acids , which included a signal peptide of 18 amino acids , a proposed propeptide of 171 amino acids , a partial mature protein of 74 amino acids . the sequences of signal peptide and propeptide are very similar to ones from wannan agkistrodon acutus reported by fan chunyan , but it only contains partial amino acids of mature protein . the 800 bp is likely to be a part of gene encoding metalloproteinase agkistrodon acutus from guangxi province 结论： 600bp产物和已报道的皖南五步蛇纤溶酶金属蛋白酶氨基酸序列相比较，有90 . 6 %的同源性； 800bp产物中信号肽及前肽和已报道的皖南五步蛇金属蛋白酶很相似，同源性为97 . 9 % ，但仅含有部分金属蛋白酶成熟肽的氨基酸序列，推测此片段为广< wp = 6 >西五步蛇金属蛋白酶原基因的一部分。
All the currently used thrombolytic agents are plasminogen activators , which are very efficient in restoring the blood flow . they can convert plasminogen into plasmin and thus degrade fibrin . despite the widespread use of established thrombolytic agents such as streptokinase , t - pa and u - pa , all these agents suffer from a number of inadequacies including resistance to reperfusion , occurrence of coronary reocclusion and bleeding complications 介绍了国内外溶栓剂蛋白质工程方面的新进展，主要涉及了组织型纤溶酶原激活剂t - pa尿激酶型纤溶酶原激活剂u - pa链激酶sk葡萄球菌激酶sak dspa及tsv - pa的研究进展。
