5 , histone acetyltransferase gene ygcns and histone deacetylase gene yrpd3 were cloned and expressed , which has laid down a foundation for studying chromosome remodeling in vitro 5 ，我们克隆并纯化了酵母中的组蛋白乙酞基转移酶基因gcns和去乙酞化酶基因rpd3 。
The activity of intact elongator complex is directed specifically toward the amino - terminal tails of histone h3 and h4 , the predominant acetylation sites are lysine - 14 of histone h3 and lysine - 8 of histone h4 完整的复合物可直接修饰组蛋白h3和h4尾部，其优先乙酰化位点是h3k14和h4k8 。
Upon extensive studies , it has been found that histone acetylation is important in cell cycle regulation . however , little is known about the mechanisms of this process up to date 随着研究的深入，人们发现组蛋白乙酰化修饰对真核细胞周期调控过程起重要作用，但对其具体的调控机制还了解不多。
Chromatin the loose network of threads seen in nondividing nuclei that represents the chromosomal material , consisting of dna , protein ( mainly histone ) , and small amounts of rna 染色质：间期细胞内由dna ，蛋白质（主要是组蛋白） ，以及少量的rna组成的线性复合结构，是间期细胞遗传物质存在的形式。
Specifically , the researchers found that isual experience in the juenile brains triggered telltale chemical alterations in substances called histones that were not triggered in the adult brains 此外，研究人员还意外发现这一视觉体验能够刺激幼鼠大脑里的组蛋白发生化学改变（修饰） ，而成年鼠则无改变。
Recent data have demonstrated that the tails of histones h3 and h4 greatly reduce the speed of transcript elongation through a nucelosome , and tail acetylation suppresses this effect 近来研究表明组蛋白尾部尤其是h3 、 h4四聚体的尾部强烈影响通过核小体的转录延伸速率，而尾部的乙酰化修饰可抑制这种影响。
They also concluded that the closure of the critical period was associated with a decrease in the ability of isual experience to drie the histone modifications that are necessary for neural rewiring 他们同时说道，神经系统的重新架构有赖于组蛋白的化学修饰，而视觉体验刺激产生化学修饰的能力下降与临界期的终止具有相关性。
As a test to determine whether such histone modification functionally affected plasticity , the researchers administered a drug to adult mice that would increase chemical modification of histone 为了确定组蛋白的化学修饰是否对大脑可塑性产生功能上的影响，研究人员做了一个试验，即给予成年鼠服用一种能够增加组蛋白化学修饰的药物。
The last seven years have spawned a vast amount of data on the enzymes that remodel and modify nucleosomes and the rules governing how transcription factors interact with the epigenetic code on histones 在过去的7年中，科学研究提供了大量的有关以下两个方面的数据： （ 1 ）具有重构和修饰核小体功能的酶，以及（ 2 ）转录因子如何同组蛋白上的表观遗传编码相互作用的机制。
It has been shown that domain ia is responsible for cell recognition , domain ii is to be involved in translocation of the toxin across membranes , and domain hi catalyzes the adp - ribosylation of elongation factor2 , which arrests protein synthesis and results in cell death 人组蛋白h3是碱性核蛋白，富含精氨酸，在生理条件下， h3的精氨酸带正电荷，而dna的磷酸基团带负电荷，所以组蛋白和dna分子主要依靠静电引力相结合。
