These cells released numbers of immune - functional molecules , such as interleukin , tnf , ifn , h2o2 and no , which protected animals from pathogen infection or tumor invasion 各种免疫功能细胞激活后，分泌各种免疫活性分子，如白细胞介素、肿瘤坏死因子及干扰素等。
Recent evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation , and to mitigate genome damage in tumour cells in response to metabolic stress 近来的证据显示：自噬提供了一个保护性功能来限制肿瘤坏死和炎症，同时减轻了肿瘤细胞内的染色体损伤来回应代谢性应激。
For example , we have found the clustering of egfr ( epidermic growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and the activation of camp - pka - creb and jnk / sapk pathways after mnng treatment 例如细胞表面受体如表皮生长因子受体、肿瘤坏死因子受体发生聚簇，细胞信号转导通路camp kacgyb和jnk sapk被激活。
Usui m , cohen ml . effects of oxidized low - density lipoprotein on vascular constraction and relaxation : clinical and pharmacological implication in atherosclerosis j life sci , 1998 , 62 ( 26 ) : 2425 庞晓，刘红阳，席燕，等.充血性心力衰竭患者血浆一氧化氮、内皮素- 1与肿瘤坏死因子-的含量及其临床意义j中国老年学杂志， 2006 ， 26 ( 2 ) ： 257
Oh cj , das km , gottlieb ab . treatment with anti2tumor necrosisfactor alpha ( tnf2alpha ) monoclonal antibody dramatically decreasesthe clinical activity of psoriasis lesions [ j ] . j a m acad dermatol , 2000 , 42 ( 5 pt 1 ) : 8292830 黄传书,金伯泉,汪美先,等.肾综合征出血热患者血浆和血清中肿瘤坏死因子活性变化[ j ] .中华医学杂志, 1992 , 72 ( 3 ) : 1512154
Univariate analysis on the survival rate revealed that the number of positive nodes , tumor size , lymphatic permeation , tumor necrosis , histologic type , histologic grade , and age were significant prognostic factors 单一变数存活分析结果显示腋下淋巴结转移，肿瘤大小，淋巴管侵袭，肿瘤坏死，肿瘤组织分类，组织学恶性度，及年龄少于30岁是有意义之预后因子。
His research work mainly concerns microcirculation , shock , fibronectin , tumor necrosis factor , dysfunction of microvascular endothelial cells and mechanism of weight - reducing . more than 200 scientific papers were published in domestic or abroad journals 近年来主要从事微循环、休克、纤维连接蛋白、肿瘤坏死因子、血管内皮细胞功能障碍及减肥机制等方面的研究，在国内外杂志上发表论文200余篇。
The life span of mouse that were inoculated tumour cells was prolonged , and the body weight increase was slowed down by injection of xhl . meanwhile , the secretion of il - 2 , tnf - a and ifn - r , that were relevant to antitumour , were enhanced by injection of xhl to mouse 荷瘤小鼠腹腔注射xhl后，在一定程度上延长了小鼠的存活时间，减缓了荷瘤小鼠体重的增加速度，同时提高了和抗肿瘤相关的白细胞介素2 、肿瘤坏死因子-和干扰素-的分泌量。
Human trail is a new member of tnf superfamily , which can specially induce cancer cell to apoptosis , but has none effect on normal cell . it is a new potential anti - cancer drug . the soluble functional part of trail gene was modified based on the partial principle code found in pichia pastoris 人的trail基因是新发现的肿瘤坏死因子tnf超家族的成员，它具有专一的诱导癌细胞调亡的作用，而对正常细胞没有任何杀伤作用，是一种很有潜力的抗癌药物。
Tumor necrosis factor ( tnf ) , a cytkine that exerts many pro - atherosclerotic effects in vivo , causes up - regulation of acat - 1 gene expression in human blood monocytes . by luciferase activity assay , tnf - a enhanced acat - 1 p7 promoter activity in thp - 1 monocytic cell line 细胞因子tnf -即肿瘤坏死因子大量存在于人动脉粥样硬化斑块中，本实验通过荧光素酶活性和rt - pcr测定结果表明， tnf -处理人血单核细胞和单核细胞株thp - 1均增强acat - 1基因p7启动子活性。
