autophosphorylation造句

• Gfral is an extracellular protein that is attached to the outer cell membrane by gpi - anchor and could not transducted signalling directly . according to the original model , a gdnf dimer first binds to either monomeric or dimeric gfral , and the gdnf - gfral complex then interacts with two ret molecules , thereby inducing their homodimerization and tyrosine autophosphorylation
  传统观点认为： gdnf首先与gfr 1结合形成gdnf - gfr 1复合物，此复合物再与ret结合形成三聚体复合物，引起ret的二聚化，并引起酪氨酸残基自磷酸化，从而引起下游的信号转导。
• Nh2 terminus lacks a " destruction box " that controls the ubiquitin - dependent degration but contains an epithdermal growth factor receptor - like autophosphorylation sequence in addition to cyclin box . the structure hints that it is not only a cyclin in cell cycle regulation but also an intracelluar signal transducer molecule . cycg has not yet been matched with a cdk binding partner , and it ' s biologic function is still elusive
  G型蛋白是细胞周期蛋白家族中的新成员，它的分子结构与多数cyclin有所不同，其n端缺少降解所需的“ destructionbox ”氨基酸序列，而c末端却包含有与表皮生长因子受体相似的自主磷酸化位点，这些表明它既是一种细胞周期蛋白，也是细胞内的信号传导分子。