etretinate造句

• Retinoid etretinate is effective for both arthritis and skin lesions.
• Roche officials said they plan to take etretinate off the market when Soriatane becomes available.
• Examples are etretinate, acitretin, isotretinoin
• It is a metabolite of etretinate, which was used prior to the introduction of acitretin.
• Etretinate has been replaced by acitretin, the free acid ( without the ethyl ester ).
• Soriatane is designed to improve on a Roche psoriasis drug currently on the market known as Tegison or etretinate.
• Soriatane, or acitretin, is designed to improve on a Roche psoriasis drug currently on the market known as Tegison or etretinate.
• While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body,
• Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life ( " t " 1 / 2 = 120 days ), making dosing difficult.
• Because of the potential for birth defects and the long time that the drug remains in a woman's system after use, etretinate is only approved for women who are past childbearing age or younger women who cannot have children.
• In contrast, acitretin's half-life is approximately 2 days . However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin.
• Though Soriatane generally doesn't stay in the body as long as etretinate, some women appear to effectively process Soriatane in a way that produces etretinate in the bloodstream, therefore posing potentially greater risks to unborn children even years after stopping Soriatane, the FDA said.
• Though Soriatane generally doesn't stay in the body as long as etretinate, some women appear to effectively process Soriatane in a way that produces etretinate in the bloodstream, therefore posing potentially greater risks to unborn children even years after stopping Soriatane, the FDA said.
• Though Soriatane generally doesn't stay in the body as long as etretinate, some women appear to effectively process Soriatane in a way that produces etretinate in the bloodstream, therefore posing potentially greater risks to unborn children even years after stopping Soriatane, the FDA said in April.
• Though Soriatane generally doesn't stay in the body as long as etretinate, some women appear to effectively process Soriatane in a way that produces etretinate in the bloodstream, therefore posing potentially greater risks to unborn children even years after stopping Soriatane, the FDA said in April.