leadzyme造句

• From left to right : leadzyme, hammerhead ribozyme, twister ribozyme
• Leadzyme has been subjected to extensive biochemical and structural characterization.
• The minimal secondary structure of leadzyme is surprisingly very simple.
• Leadzyme is thought to perform catalysis using a two-step mechanism.
• However, in leadzyme this product is just an intermediate.
• The leadzyme is thought to have a highly dynamic structure.
• This is also supported by the fact the reaction of the leadzyme is pH dependent.
• Examples of ribozymes include the hammerhead ribozyme, the VS ribozyme, Leadzyme and the hairpin ribozyme.
• They also showed that leadzyme motif is very common in the mRNA sequences of these organisms as well.
• This is shown in top figure on right, which is the secondary structure of leadzyme generated using mfold.
• Recently using time-resolved spectroscopy, it was shown that the active site of leadzyme is very dynamic.
• The crystal structure is consistent with a two-metal ion mechanism that has been proposed for leadzyme catalysis.
• In the ground state, leadzyme binds a single Sr 2 + ion at nucleotides G43, G45 and A45.
• The cleavage site of leadzyme is located within a four-nucleotide long asymmetric internal loop that also consists of RNA helices on its both sides.
• The structures of leadzyme have also been solved using X-ray crystallography and NMR . The crystal structures of the two conformations of leadzyme are shown in the lower figure on right.
• The structures of leadzyme have also been solved using X-ray crystallography and NMR . The crystal structures of the two conformations of leadzyme are shown in the lower figure on right.
• Since leadzyme is a relatively simple motif i . e ., it has a simple fold, it appears that there are many sequences in the genomes of many natural systems which can potentially fold into a leadzyme structure.
• Since leadzyme is a relatively simple motif i . e ., it has a simple fold, it appears that there are many sequences in the genomes of many natural systems which can potentially fold into a leadzyme structure.
• Consistent with these studies, a high-resolution crystal structure also revealed two distinct conformations of the leadzyme with different binding sites for Mg 2 + and Sr 2 + ( Pb 2 + substitutes ) in the two conformations.