taxanes造句

• Patients who have progressed after receiving anthracyclines and taxanes are eligible.
• Taxanes are natural and semi-synthetic drugs.
• Taxanes present difficulties in formulation as medicines because they are poorly soluble in water.
• For example, the vinca alkaloids and taxanes selectively bind and inhibit microtubules, leading to cell cycle arrest.
• The synthesis of related taxanes " decinnamoyltaxinine E " and " taxabaccatin III " has been reported
• Both medications belong to a class of chemotherapy drugs called taxanes, which are widely used in several types of cancers.
• The vinca alkaloids thus prevent microtubule " polymerization ", as opposed to the mechanism of action of taxanes.
• They are the first new class of drugs for cancer in a decade since the taxanes were developed in the late 1980s.
• Other examples of microtubule-stabilizing agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin.
• All species of yew contain highly poisonous alkaloids known as taxanes, with some variation in the exact formula of the alkaloid between the species.
• In oncology, class III ?-tubulin has been investigated as both a prognostic biomarker and an indicator of resistance to taxanes and other compounds.
• Recently, the presence of taxanes in the shells and leaves of " Corylus avellana " ( the common hazel plant ) has been reported.
• While taxanes like Paclitaxel and docetaxel have been used successfully against non small-cell lung cancers, intrinsic and acquired drug resistance limit their anticancer properties.
• Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials epithilones have better efficacy and milder adverse effects than taxanes.
• Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials epithilones have better efficacy and milder adverse effects than taxanes.
• The optimal dose scheduling of taxanes remains unconfirmed, but most studies find significant mortality benefit following either a three-week or a one-week administration schedule.
• Another commercial semisynthesis ( by the company " Natural Pharmaceuticals " ) relies on the isolation of a group of paclitaxel derivatives isolated from primary ornamental taxanes.
• The taxoids class and the taxanes class both include paclitaxel ( trade names Taxol, Abraxane, Onxol, Nov-Onxol ) and docetaxel ( trade names Taxotere, Docecad ).
• Unlike taxanes, taccalonolides appear to work through a different mechanism of action that does not involve tubulin, although recently isolated taccalonolides AF and AJ have shown tubulin-interaction activity.
• The arils are edible and sweet, but the seed is dangerously poisonous; unlike birds, the human stomach can break down the seed coat and release the taxanes into the body.