First of all , the paper introduces the pre - prepare work for the algorithm , that is the pre - processing of gene chip images . the part includes denoise and segmentation . the method of denoising is wavelet denoising with phase preserving and the segmentation is adaptive thresholding . finally , the acquired denoised binary image is referred to input image for the algorithm 这一部分分为去噪和分割两步,其中去噪方法使用的是相位保留小波去噪法,分割方法使用的是自适应阈值分割,最终得到被去噪的二值图像,其被用作算法的输入图像。