oncogenes中文是什么意思

• (oncogene 的复数) [化] 致癌基因

• oncogenes and cancer    第二十八章 致癌基因和癌症
• oncogenes,abl    《英文msh词典》Oncogenes,abl ; [入口词] Oncogenes,abl ; [主题词] Genes,abl ; [英文释义] Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
• oncogenene    致癌基因
• oncogenes,bcr-v-abl    《英文msh词典》Oncogenes,bcr-v-abl ; [入口词] Oncogenes,bcr-v-abl ; [主题词] Genes,abl ; [英文释义] Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
• oncogene-coded growth factor    肿瘤基因译码生长因子
• oncogenes,jun    《英文msh词典》Oncogenes,jun ; [入口词] Oncogenes,jun ; [主题词] Genes,jun ; [英文释义] Retrovirus-associated DNA sequences (jun) originally isolated from the avian sarcoma virus 17 (ASV 17). The proto-oncogene jun (c-jun) codes for a nuclear protein which is involved in growth-related transcriptional control. Insertion of c-jun into ASV-17 or the constitutive expression of the c-jun protein produces tumorgenicity. The human c-jun gene is located at 1p31-32 on the short arm of chromosome 1.
• oncogene,v-src    《英文msh词典》Oncogene,v-src ; [入口词] Oncogene,v-src ; [主题词] Genes,src ; [英文释义] Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.
• oncogenes,mos    《英文msh词典》Oncogenes,mos ; [入口词] Oncogenes,mos ; [主题词] Genes,mos ; [英文释义] Retrovirus-associated DNA sequences (mos) originally isolated from the Moloney murine sarcoma virus (Mo-MSV). The proto-oncogene mos (c-mos) codes for a protein which is a member of the serine kinase family. There is no evidence as yet that human c-mos can become transformed or has a role in human cancer. However,in mice,activation can occur when the retrovirus-like intracisternal A-particle inserts itself near the c-mos sequence. The human c-mos gene is located at 8q22 on the long arm of chromosome 8.
• oncogene,v-sis    《英文msh词典》Oncogene,v-sis ; [入口词] Oncogene,v-sis ; [主题词] Genes,sis ; [英文释义] Retrovirus-associated DNA sequences (v-sis) originally isolated from the simian sarcoma virus (SSV). The proto-oncogene c-sis codes for a growth factor which is the B chain of PLATELET-DERIVED GROWTH FACTOR. v-sis or overexpression of c-sis causes tumorigenesis. The human sis gene is located at 22q12.3-13.1 on the long arm of chromosome 22.
• oncogenes,myb    《英文msh词典》Oncogenes,myb ; [入口词] Oncogenes,myb ; [主题词] Genes,myb ; [英文释义] Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts,Dictionary of Cytokines,1995).
• oncogene,v-rel    《英文msh词典》Oncogene,v-rel ; [入口词] Oncogene,v-rel ; [主题词] Genes,rel ; [英文释义] Family of retrovirus-associated DNA sequences (v-rel) originally isolated from an avian reticuloendotheliosis virus strain. The proto-oncogene rel (c-rel) codes for a subcellular (nuclear and cytoplasmic) transcription factor that has a role in lymphocyte differentiation. Translocation or overexpression of c-rel or competition from v-rel causes oncogenesis. The human rel gene is located at 2p12-13 on the short arm of chromosome 2.

• In order to find an explanation and to determine the possible mechanism of these biological effects, many in vitro and in vivo studies of emf effects have been published . these studies were involved in many enzymes ( such as odc, succinate dehydrogenase, pkc ), pro-oncogene ( c-myc, c-fos, etc . ), gap junction and protein synthesis, and so on
  为了揭示工频磁场生物效应的机制，尤其是与肿瘤发生发展的关系，人们开展了较为广泛的体内及体外的实验研究，涉及到各种生物酶类(odc、琥珀酸脱氢酶、pkc等)、原癌基因(c-myc、c-fos等)、细胞间缝隙连接及蛋白合成等方面。
• For example, as a direct toxic effect, periodontal iruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto-oncogenes or alter signaling pathways that affect cell proliferation or surial of epithelial cells
  例如，作为直接毒性作用，牙周病毒和细菌及在细胞周围其产生的毒性物质（例如，类毒素或酶类）可直接诱导肿瘤抑制基因和原癌基因突变或者改变细胞信号传导通路从而影响上皮细胞增殖或存活。
• Pp38 was found to have immunosuppressive effect on chicken in vivo and the copy number of 132-bpr was found to be associated with the attenuation of the virus in vitro, meq was believed to be a potential oncogene, based on its leucine zipper structure and proline-rich domain characteristic of jun / fos family of transcription factors, and may plays an important role in the pathogenicity or oncogenicity of mdv
  其中，meq与132-bpr两个基因是mdv-1所特有，已证实132-bpr的拷贝数与毒株的体外致弱程度有关，pp38则被证实可抑制机体的免疫应答。meq基因由于具有与致瘤基因junfos家族类似的分子结构，因此，我们有理由认为meq基因在mdv致病、致瘤中可能发挥重要的作用。
• On the other hand, the expression is repressed by the proto-oncogenes n-myc and c-myc, and in some cases the expression is also repressed by testosterone or dihydrotestosterone ( androgen ) at mrna level infering from all the references that can be obtained, the functions of ndrg family may be involved in cellular differentiation events > maintaining the balance of cell redox potential ( in oxidative stress condition or biological conversion process ), or counteracting cell malignant transformation, and so on
  综合己有的文献，推测ndrg家族可能参与细胞生长分化、维持细胞氧化还原电势平衡（氧化应激或生物转化）、阻止肿瘤细胞恶化等。因此，研究其在细胞中的具体功能以及可能的信号通路将具有非常重要的意义。深人研究ndrgz在体内的组织细胞和亚细胞水平分布特点及其功能，需要高效价和高特异性的ndrgz抗体。
• For example, as a direct toxic effect, periodontal viruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto-oncogenes or alter signaling pathways that affect cell proliferation or survival of epithelial cells
  例如，作为直接毒性作用，牙周病毒和细菌及在细胞周围其产生的毒性物质（例如，类毒素或酶类）可直接诱导肿瘤抑制基因和原癌基因突变或者改变细胞信号传导通路从而影响上皮细胞增殖或存活。
• The members of src family are non-receptor tyrosine kinases . their make an important function in a complex network of intracellular signals, such as cell growth, proliferation, transformation, apoptosis, and cell adhesion, migration . the fact that src was discovered as an oncogene suggests that src could closely involvement in cancer
  而今，src已发展成为包括九个成员在内的激酶家族，隶属于非受体酪氨酸激酶，是细胞信号转导途径中一类重要的信号分子，调控细胞的生长，增殖，凋亡，细胞黏附与迁移等一系列功能。