pemt造句

• Although the enzymatic structure is unknown, PEMT is proposed to contain four hydrophobic membrane-spanning regions, with both its C and N termini on the cytosolic side of the ER membrane.
• A single-nucleotide polymorphism ( G to C ) in the promoter region of the PEMT has been demonstrated to contribute to development of organ dysfunction in conjunction with a low-choline diet.
• Furthermore, PC made via PEMT plays a wide range of physiological roles, utilized in choline synthesis, hepatocyte membrane structure, bile secretion, and very-low-density lipoprotein ( VLDL ) secretion.
• This demand may be met by upregulation of PEMT via increasing estrogen levels to produce more choline " de novo ", but even with increased PEMT activity, the demand for choline is still so high that bodily stores are generally depleted.
• This demand may be met by upregulation of PEMT via increasing estrogen levels to produce more choline " de novo ", but even with increased PEMT activity, the demand for choline is still so high that bodily stores are generally depleted.
• The PEMT deficient mice showed elevated plasma glucagon levels, increased hepatic expression of glucagon receptor, insulin receptor substrate 1 ( IRS1-s307 ), which blocks insulin-mediated signal transduction; together, these contribute to enhanced gluconeogenesis and ultimately insulin resistance.
• PEMT activity is unrelated to enzyme mass, but rather is regulated by supply of substrates including PE, as well as PMME, PDME, and SAM . Low substrate levels inhibit PEMT . The enzyme is further regulated by S-adenosylhomocysteine produced after each methylation.
• PEMT activity is unrelated to enzyme mass, but rather is regulated by supply of substrates including PE, as well as PMME, PDME, and SAM . Low substrate levels inhibit PEMT . The enzyme is further regulated by S-adenosylhomocysteine produced after each methylation.
• While the CDP-choline pathway, in which choline obtained either by dietary consumption or by metabolism of choline-containing lipids is converted to PC, accounts for approximately 70 % of PC biosynthesis in the liver, the PEMT pathway has been shown to have played a critical evolutionary role in providing PC during times of starvation.