Spatial resolution deficit pattern , after administration for 10 days , water maze test was adapted to train mice for successive 5 days . a blank control group received ip of equivalent normal saline , the remaining 5 groups received ip of 15mg / kg pentobarbital sodium at 30min before training everyday , mice were administrated 1 time during training 空间分辨障碍小鼠，连续给药10天后，采用水迷宫法连续训练5天，每天y ！ i练前30ndn ，腹腔注射戊巴比妥钠15mg kg 。训练过程中每天给药1次。
We have studied pharmacodynamics of valepotriates through observing its effects on the times of spontaneous motion in mice , the sleep time of sodium pentobarbital ( superthreshold doses ) , sleep rate of sodium pentobarbital ( subthreshold doses ) , the number of writhes induced by acetic acid and seizures rate of metrazol . the experiment results proved that valepotriates could significantly decrease the times of spontaneous motion , prolong the sleep time of sodium pentobarbital ( superthreshold doses ) , enhance the sleep rate of sodium pentobarbital ( subthreshold doses ) , reduce the number of writhes induced by acetic acid and reduce the seizures rate of metrazol , so it showed high central inhibition effect , thus offer scientific foundation for its further exploitation and utilization 通过研究蜘蛛香中总缬草素对小鼠自发活动的影响、对戊巴比妥钠睡眠时间的影响、对戊巴比妥钠阈下剂量的影响、对小鼠扭体反应的影响、对戊四氮诱发惊厥的影响发现：总颗草素能明显抑制小鼠的自主活动，显著延长戊巴比妥钠致小鼠睡眠时间，明显提高阈下剂量戊巴比妥钠小鼠入睡数，对抗戊四氮诱发的小鼠惊厥，显示出较好的中枢抑制作用，为蜘蛛香的进一步研究开发提供了科学依据。
1 solid - phase extraction of barbitone - - ultraviolet differential derivative spectrophotometry in this paper the solid - phase extraction and uv differential derivative spectrophotometry quantitative determination method for 5 of drugs , including barbital , phenobarbital , pentobarbital , amobarbital and secobarbital in blood , urine , liver , kidney , lung and brain 1巴比妥药物固相萃取? ?紫外差示导数光谱检测法本文建立了血、尿、肝、肾、肺、脑中巴比妥、苯巴比妥、戊巴比妥、异戊巴比妥、速可眠的分析方法。
