Administered orally to female rats was reported to cause a severe , long - lasting reduction in fertility , the contraceptive effects was probably not due to stevioside 以管饲法给老鼠喂服每日份量高达每千克体重1000毫克的甜菊糖? ，并没有畸胎或胚胎中毒的情况。
Stevioside may also act as a calcium antagonist , showing a hypotensive effect and inducing diuresis , natriuresis and a fall in reabsorption of glucose in the renal tubules 甜菊糖是钙对抗物，可引致低血压尿液及尿钠排泄增多，并可降低肾小管重新吸收葡萄糖的能力。
Stevioside may also act as a calcium antagonist , showing a hypotensive effect and inducing diuresis , natriuresis and a fall in reabsorption of glucose in the renal tubules 甜菊糖?是钙对抗物，可引致低血压、尿液及尿钠排泄增多，并可降低肾小管重新吸收葡萄糖的能力。
Before reviewing stevioside again , the committee considered that it would be necessary to develop specifications to ensure that the material tested was representative of the commercial product 再次评估甜菊糖前，委员会认为必须为甜菊糖制订性质规范，确保化验物能代表有关商品。
Neither teratogenic nor embryotoxic effect were observed in rats given stevioside at doses of up to 1000mg kg of body weight per day by gavage . the results of genotoxicity tests with stevioside in various 在仓鼠身上，配基甜菊醇的毒性较甜菊糖剧烈，但这现象没有在大鼠身上出现。
Before reviewing stevioside again , the committee considered that it would be necessary to develop specifications to ensure that the material tested was representative of the commercial product 再次评估甜菊糖?前，委员会认为必须为甜菊糖?制订性质规范，确保化验物能代表有关商品。
Neither teratogenic nor embryotoxic effect were observed in rats given stevioside at doses of up to 1000mgkg of body weight per day by gavage . the results of genotoxicity tests with stevioside in various 在仓鼠身上， ?配基甜菊醇的毒性较甜菊糖?剧烈，但这现象没有在大鼠身上出现。
The fact that stevioside is glycosylated at position c13 could explain the absence of mutagenicity . the active metabolite of steviol responsible for its mutagenic activity is not known 甜菊糖?的c13位置被糖基化，是没有引起突变的原因。目前，还没有找出引发突变能力的甜菊醇活性代谢物。
Administered orally to female rats was reported to cause a severe , long - lasting reduction in fertility , the contraceptive effects was probably not due to stevioside 有研究显示，给雌性大鼠灌输口服的甜叶菊水剂，可导致生殖能力严重下降，并且效果持久，不过，这些避孕效果很可能与甜菊糖无关。
Further information on the nature of the substance that was tested , data on the metabolism of stevioside in humans and the results of suitable in vivo genotoxicity studies with steviol would also be necessary 此外，委员会还需要有关化验物性质的资料，甜菊糖在人体内新陈代谢的数据，以及甜菊醇在适当活体内的基因毒性研究结果。
