甜菊醇

• Several mechanistic studies indicated that the structural features necessary for the expression of mutagenic activity include a hydroxyl group at position c13 and an unsaturated bond joining the c16 and c17 carbon atoms of steviol
  多项生理机能研究显示，显露基因突变的特性结构位于甜菊醇c13位置的羟基组，以及连结c16和c17碳原子的不饱和链。
• Stevioside has not been previously evaluated by the committee . after oral administration to rats , stevioside is not readily absorbed from the upper small intestine but is hydrolysed to the aglycone , steviol , before absorption from the gut
  甜菊糖?喂食大鼠后，并不会在上小肠马上被吸收，而是先水解为配基( aglycone )甜菊醇，才被肠道吸收。
• The active metabolite of steviol responsible for its mutagenic activity is not known . while some data suggest that epoxidation may be involved in the metabolic activation of steviol , other data indicate that the active metabolite is not an epoxide
  有些数据指出，甜菊醇在代谢活化的过程中，可能牵涉环氧化作用，但其他数据显示，甜菊醇的活性代谢物并不是环氧化物。
• The committee noted a number of shortcomings in the information available on stevioside . in several studies , the material tested stevioside or steviol was poorly specified or of variable quality , and no information was available on other constituents or contaminants
  在几项研究中，使用的化验物甜菊糖或甜菊醇均缺乏规范，或质素参差，而化验物含有的其他成分或污染物的资料亦付诸阙如。
• While some data suggest that epoxidation may be involved in the metabolic activation of steviol , other data indicate that the active metabolite is not an epoxide . preliminary data indicate that steviol may be activated to a mutagenic metabloite by human liver microsomes
  有些数据指出，甜菊醇在代谢活化的过程中，可能牵涉环氧化作用，但其他数据显示，甜菊醇的活性代谢物并不是环氧化物。
• In several studies , the material tested ( stevioside or steviol ) was poorly specified or of variable quality , and no information was available on other constituents or contaminants . furthermore , no studies of metabolism of stevioside and steviol in humans were available
  在几项研究中，使用的化验物(甜菊糖?或甜菊醇)均缺乏规范，或质素参差，而化验物含有的其他成分或污染物的资料亦付诸阙如。
• The aglycone , steviol , exhibited greater acute toxicity than stevioside in hamsters but not in rats . steviol was clearly genotoxic after metabolic activation , inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
  甜菊醇经过代谢活化后，基因毒性明显，可引致细菌产生正向突变，以及使中国仓鼠的肺纤维原细胞产生基因突变和染色体变异。
• The aglycone , steviol , exhibited greater acute toxicity than stevioside in hamsters but not in rats . steviol was clearly genotoxic after metabolic activation , inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
  甜菊醇经过代谢活化后，基因毒性明显，可引致细菌产生正向突变，以及使中国仓鼠的肺纤维原细胞产生基因突变和染色体变异。