ad5造句

• For example, oncolytic vaccines based on the Ad5 serotype have relatively poor clinical efficacy as monotherapies.
• The most commonly used group of adenoviruses is serotype 5 ( Ad5 ), whose binding to trimer.
• This restricts " Ad5-?24E3 " to replication only in proliferating cells, such as tumour cells.
• Although expressed widely in epithelial cells, CAR expression in tumours is extremely variable, leading to resistance to Ad5 infection.
• Retargeting of Ad5 from CAR, to another receptor that is ubiquitously expressed on cancer cells, may overcome this resistance.
• Traditional research has focussed on species C Adenovirus serotype 5 ( Ad5 ) for creating oncolytic vaccines for the potential use as cancer treatment.
• The vaccine was created using a mixture of three components, each of which was made in the laboratory with a replication-defective version of Ad5.
• Notably, investigators in the study reported a higher risk of HIV infection was found among participants who had an existing immunity to the common cold virus ( known as adenovirus type 5 or Ad5 ).
• Several adenoviruses, including Ad5, Ad9, Ad31, Ad36, Ad37, and SMAM1, have at least some evidence of causation of obesity in animals, adipogenesis in cells, and / or association with human obesity.
• The 70C, 80C, 90C and 100C models, used for ploughing, received just a few structural changes to become the AD3, AD4, AD5, AD6, AD7, AD9, AD1O, AD12, AD14, AD18 and AD20 crawler loaders.
• Secondly, promotion prospects for administrators are extremely poor; the Commission's own statistics reveal that an average career progression from AD5 to AD14 ( Director level ) takes 35 40 years, obviously unattainable for the average entrant who joins at 34 years old.
• This hybrid of adenovirus serotypes Ad11p and Ad3 shows much higher potency and tumour selectivity than the control viruses ( including Ad5, Ad11p and Ad3 ) and was confirmed to generate approximately two logs more viral progeny on freshly isolated human colon tumour tissue than on matching normal tissue.
• A conditionally replicative adenovirus ( CRAd ) with a 24 base pair deletion in the retinoblastoma-binding domain of the E1A protein ( " Ad5-?24E3 " ), is unable to silence retinoblastoma, and therefore unable to induce S-phase in host cells.