adenylosuccinate造句

• The monomer of adenylosuccinate lyase has three domains.
• This step is catalyzed by adenylosuccinate lyase.
• Adenylosuccinate lyase belongs to the ?-elimination superfamily, and as such its structure is a homotetramer.
• Mutated adenylosuccinate lyase ( ASL ) causes clinical disease in patients that is referred to as adenylosuccinate lyase deficiency.
• Mutated adenylosuccinate lyase ( ASL ) causes clinical disease in patients that is referred to as adenylosuccinate lyase deficiency.
• Adenylosuccinate lyase is part of the ?-elimination superfamily of enzymes and it proceeds through an E1cb reaction mechanism.
• "' Hadacidin "', and hadacidin analogues, have anticancer activity and activity against adenylosuccinate synthetase.
• First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for a nitrogen and forming the intermediate adenylosuccinate.
• First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for a nitrogen and forming the intermediate adenylosuccinate.
• "' Adenylosuccinate "'is an intermediate in the interconversion of purine nucleotides inosine monophosphate ( IMP ) and adenosine monophosphate ( AMP ).
• Adenylosuccinate lyase in humans and " Bacillus subtilis " can be kinetic studies with APBADP show that the substrates for both reactions use the same active site.
• The crystal structure of adenylosuccinate synthetase from E . coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands.
• The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and requires the input of energy from a phosphoanhydride bond in the form of guanosine triphosphate ( GTP ).
• The second stage is the formation of adenylosuccinate from IMP and the amino acid aspartate, which is coupled to the energetically favourable hydrolysis of GTP, and catalysed by the enzyme adenylosuccinate synthetase:
• The second stage is the formation of adenylosuccinate from IMP and the amino acid aspartate, which is coupled to the energetically favourable hydrolysis of GTP, and catalysed by the enzyme adenylosuccinate synthetase:
• The number of disease-causing genotypes keeps increasing as more mutations are discovered, and now thirty different point mutations have been identified so far, and one deletion, that cause adenylosuccinate lyase deficiency.
• In the ASL-catalyzed reaction splitting adenylosuccinate into adenosine monophosphate ( AMP ) and fumarate, the AMP must rotate slightly after the reaction is complete and before fumarate is released in order for both products to fit in the active site.
• A recent study conducted by Sridharan et al . ( AJP Cell Physiology, 2008, 295 : C29-C37 ) showed that activation of HIF-1? allows cardiomyocytes to sustain mitochondrial membrane potential during anoxic stress by utilizing fumarate produced by adenylosuccinate lyase as an alternate terminal electron acceptor in place of oxygen.
• Adenylosuccinate lyase deficiency ( MIM 103050, ADSL ) is a rare autosomal recessive disease causing severe mental retardation and / or autistic features . 1, 2 Seizures are often observed ( 80 % ), 3 varying in age of onset ( from newborn to late childhood ) and nature ( tonic-clonic,  suppression burst pattern, West syndrome, etc . ), and are very often resistant to all medication.
• In molecular biology, "'Adenylosuccinate synthase "'( or "'adenylosuccinate synthetase "') ( ) is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate ( GTP )-dependent conversion of inosine monophosphate ( IMP ) and aspartic acid to guanosine diphosphate ( GDP ), phosphate and N ( 6 )-( 1, 2-dicarboxyethyl )-AMP . Adenylosuccinate synthetase has been characterised from various sources ranging from " Escherichia coli " ( gene purA ) to vertebrate tissues.