aggresomes造句

• Disruption of microtubules blocks the formation of aggresomes.
• Similarly, inhibition of proteasome function also prevents the degradation of unassembled presenilin-1 molecules leading to their aggregation and deposition in aggresomes.
• These aggresomes form at the microtubule organizing center ( MTOC or centrosome ) following retrograde transport of misfolded proteins by the dynein motor protein.
• It is intriguing to speculate whether aggresomes are similar to the ubiquitin-positive inclusion bodies that are the pathological hallmark of neurodegenerative diseases, such as the Lewy bodies in Parkinson's disease.
• Some pathological proteins, such as alpha-synuclein, cannot be degraded and cause the aggresomes to form inclusion bodies ( in Parkinsons Disease, Lewy bodies ) which contribute to neuronal dysfunction and death.
• Dr . Kopito studies of the  " F508 mutant for of CFTR lead to the discovery of a second fundamental cellular response to misfolded proteins, which is the sequestration of this misfolded proteins into inclusion bodies called aggresomes.
• In the s-IBM muscle fibers, there is evidence of misfolding of proteins, pathologic proteinaceous inclusions including aggresomes, abnormalities of the two protein-disposal systems involving the ubiquitin proteasome pathway and the lysosomes, mitochondrial dysfunctions, and oxidative stress.