aprepitant造句

• Aprepitant is taken orally in the form of a capsule.
• An example of a drug in this class is aprepitant.
• Larsen said aprepitant worked on the brain in a different way than established antidepressant drugs.
• Once this step has been successfully completed a stable molecule of aprepitant has been produced.
• Aprepitant is made up of a morpholine core with two substituents attached to adjacent ring carbons.
• It is a prodrug of aprepitant.
• Aprepitant is an off-white crystalline solid that has a molecular weight of around 534.53.
• Aprepitant is classified as an NK 1 antagonist because it blocks signals given off by NK 1 receptors.
• The actions of aprepitant are said to be entirely central, thus requiring passage of the drug into the central nervous system.
• Improved antiemetics such as ondansetron and analogues, as well as aprepitant have made aggressive treatments much more feasible in cancer patients.
• Shortly after Merck initiated research into the reducing the severity and likelihood of CINV, researchers discovered that aprepitant is effective in prevention.
• This more streamlined route yields around 76 % more aprepitant than the original process and reduces the operating cost by a significant amount.
• As a moderate inhibitor of CYP3A4, aprepitant can increase plasma concentrations of co-administered medicinal products that are metabolized through CYP3A4.
• This would, therefore, suggest that aprepitant as a whole, despite having components that are polar, is a non-polar substance.
• Researchers worked on coming up with a process to create aprepitant, and within a short period they came up with effective synthesis of the substance.
• Aprepitant works by controlling levels of " substance P, " a protein fragment present in parts of the brain linked to emotion and stress.
• Aprepitant is the active ingredient in a Merck drug launched last April, Emend, which relieves nausea induced by high-dose chemotherapy treatment in cancer patients.
• Last week, Merck said it halted development of a drug called aprepitant, which would have been its first entrant in the huge market for depression treatments.
• Positron emission tomography ( PET ) studies, have demonstrated that aprepitant can cross the blood brain barrier and bind to NK 1 receptors in the human brain.
• The company said Wednesday that it recently halted clinical development trials of the compound, called aprepitant or MK-0869, because it had failed to work as expected.