autophagosomal造句

• The pre-autophagosomal structure in yeast is described as a complex localized near the vacuole.
• Knocking out either of these SNAREs leads to accumulation of small Atg9 containing vesicles that do not fuse, therefore preventing the formation of the pre-autophagosomal structure.
• For example, LC3 in mammals is Atg8 in yeast and autophagosomes are generated from Pre-Autophagosomal Structure ( PAS ) which is distinct from the precursor structures in mammalian cells.
• One of them is LC3 ( MAP1LC3A ), a light chain of the microtubule-associated protein 1 Like Atg8, LC3 needs to be proteolytically cleaved and lipidated to be turned into its active form which can localize to the autophagosomal membrane.
• The pre-autophagosomal structure ( PAS ) is localized by the IPOD . However, it wasn't shown that IPOD substrates are delivered to the vacuole, and so the link between the IPOD and autophagy is yet to be determined.