cyclooxygenases造句

• Aspirin and other NSAIDs are inhibitors of the cyclooxygenases.
• In cells of the kidney, cyclooxygenases catalyse the conversion of paracetamol into oxidative damage.
• Inhibition of cyclooxygenases therefore rather selectively damages the renal papillae, increasing the risk of renal papillary necrosis.
• Cyclooxygenases are enzymes known to play a large role in inflammatory processes through oxidation of unsaturated fatty acids.
• Examples include HIV-1 protease, racemases, ?-lactamases, metalloproteinases, cyclooxygenases and many others.
• It meant, Simmons and the other discoverers of the enzyme realized, that aspirin and similar drugs might be blocking both cyclooxygenases.
• "' NS-398 "'is a COX-2 inhibitor used in the study of the function of cyclooxygenases.
• In laboratory studies, for example, NSAIDs that don't act on cyclooxygenases are still able to slow or reverse cancer-related changes in cells.
• Dioxygenases include lipoxygenases ( plants, animals, fungi ), heme-dependent fatty acid oxygenases ( plants, fungi ), and cyclooxygenases ( animals ).
• COX 1 and 2 are key enzymes of the arachidonic acid pathway and it has been shown that inhibitors of theses cyclooxygenases have implications for treating rheumatoid arthritis.
• Lured by those multibillion-dollar markets, pharmaceutical companies began about a decade ago to develop a safer NSAID . The compounds work by targeting enzymes called cyclooxygenases that help build prostaglandins.
• In response to an antigen, a chronic, submucosal, T cell mediated inflammatory response occurs, which involves cytokines ( e . g . tumor necrosis factor alpha ), protease-activated receptors, matrix metalloproteinases and cyclooxygenases.
• Biochemical studies have elucidated the mechanism of action of pure harpagoside, showing that it moderately inhibited cyclooxygenases 1 and 2 of the arachidonic acid pathway ( COX  1 / 2 ) and overall nitric oxide production in human blood.
• LA is converted by various lipoxygenases, cyclooxygenases, certain cytochrome P450 enzymes ( the CYP monooxygenases ), and non-enzymatic autooxidation mechanisms to mono-hydroxyl products viz ., 13-Hydroxyoctadecadienoic acid and 9-Hydroxyoctadecadienoic acid; these two hydroxy metabolites are enzymatically oxidized to their keto metabolites, 13-oxo-octadecadienoic acid and 9-oxo-octadecdienoic acid.