emodepside造句

• In addition to exerting an effect on the nematode via binding to Latrophilin receptors, there is also recent evidence that indicates that emodepside also interacts with the BK potassium channel coded by the gene Slo-1.
• Both LAT-1 / LAT-2 and slo-1 mutants ( reduction / loss of function ) show significant resistance to emodepside with it being conceivable that the presence of both is required for emodepside to induce its full effect.
• Both LAT-1 / LAT-2 and slo-1 mutants ( reduction / loss of function ) show significant resistance to emodepside with it being conceivable that the presence of both is required for emodepside to induce its full effect.
• As IP3 receptors have sparse or little distribution throughout the pharyngeal nervous system of C . elegans ( one of the tissues where LAT-1 agonists such as ?-LTX and emodepside have their most predominant effects ) it has been concluded that it is the DAG component of the cascade that regulates neurotransmitter release.
• The presumable effect that emodepside interaction with these channels would exert on the neuron would be to activate the channel causing potassium ion efflux, hyper-polarization and subsequent inhibition of excitatory neurotransmitter effect ( acetylcholine if acting at the neuromuscular junction ), having an inhibitory effect on synaptic transmission, the production of postsynaptic action potentials and ultimately muscle contraction ( manifesting itself as paralysis or reduced pharyngeal pumping ).