exportin造句

• The tRNA exporter in vertebrates is called " exportin-t ".
• This causes a shape change in exportin, increasing its affinity for the export cargo.
• Nuclear export first begins with the binding of Ran-GTP ( a G-protein ) to exportin.
• Actin is exported at least in two ways, through exportin 1 ( EXP1 ) and exportin 6 ( Exp6 ).
• Actin is exported at least in two ways, through exportin 1 ( EXP1 ) and exportin 6 ( Exp6 ).
• Once the cargo is bound, the Ran-exportin-cargo complex moves out of the nucleus through the nuclear pore.
• This process is also energy dependent as it consumes one GTP . Export with the exportin CRM1 can be inhibited by Leptomycin B.
• Once no longer bound to Ran, the exportin molecule loses affinity for the nuclear cargo as well, and the complex falls apart.
• GTPase activating proteins ( GAPs ) then hydrolyze the Ran-GTP to Ran-GDP, and this causes a shape change and subsequent exportin release.
• Exportin and Ran-GDP are recycled to the nucleus separately, and guanine exchange factor ( GEF ) in the nucleus switches the GDP for GTP on Ran.
• Following export from the nucleus by exportin-5, pre-mir-155 molecules are cleaved near the terminal loop by Dicer resulting in RNA duplexes of ~ 22nucleotides.
• The association of this exportin CAS binding domain is Ran-GTP dependent, and hydrolysis of GTP leads to dissociation of importin ? from the exportin CAS-Ran complex.
• The association of this exportin CAS binding domain is Ran-GTP dependent, and hydrolysis of GTP leads to dissociation of importin ? from the exportin CAS-Ran complex.
• Then the " cellular apoptosis susceptibility protein " ( CAS ), an exportin which in the nucleus is bound to RanGTP, displaces Importin-? from the cargo.
• Nuclear export is similar, as the exportin binds the cargo inside the nucleus in a process facilitated by RanGTP, exits through the nuclear pore, and separates from its cargo in the cytoplasm.
• Microprocessor cleavage of pri-miRNAs typically occurs co-transcriptionally and leaves a characteristic RNase III single-stranded overhang of 2-3 nucleotides, which serves as a recognition element for the transport protein exportin-5.
• In the classical export scheme, proteins with a " nuclear export sequence " ( NES ) can bind in the nucleus to form a heterotrimeric complex with an exportin and RanGTP ( for example the exportin CRM1 ).
• In the classical export scheme, proteins with a " nuclear export sequence " ( NES ) can bind in the nucleus to form a heterotrimeric complex with an exportin and RanGTP ( for example the exportin CRM1 ).
• The C-terminus domain of importin ?, which include the tenth ARM repeat, is responsible for interacting with exportin CAS, another karyopherin protein that functions in recycling importin ? from the nucleus back into the cytoplasm of the cell.
• In wild-type cells, macromolecules in the nucleus with the leucine-rich nuclear export signal ( NES ) can be transported to the cytoplasm by binding to a karyopherin protein called chromosome region maintenance 1 ( CRM1 ) / exportin 1.