fabp1造句

• Studies with mice to determine the effect of suppressing the FABP1 gene have been performed.
• Nine are well established ( FABP1-9 ) with a recently discovered tenth ( FABP12 ).
• FABP6 and FABP1 ( the liver fatty acid binding protein ) are also able to bind bile acids.
• Increased BMI and insulin resistance in subjects demonstrated higher serum FABP1 with a particular correlation in subjects with central adiposity.
• On exon 3 of the human FABP1 gene an Ala to Thr substitution has been identified leading to a T94A missense mutation.
• A study in Chinese young adults indicates a strong relationship between serum FABP1 levels and lipid profile, body measurements and homeostatic parameters.
• Alternately obesity may in fact lead the human body to develop resistance to the actions of FABP1 leading to the compensatory up-regulation.
• FABP1 has been found to have a unique structure compared to other members of the FABP family, allowing it to bind multiple ligands simultaneously.
• When provided with high-fat or high-cholesterol based diets those with suppressed FABP1 expression demonstrated a significant impact on metabolic regulation and weight gain.
• FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids ( LCFAs ) and other hydrophobic molecules.
• The human FABP1 gene is located on the short ( p ) arm of chromosome 2 from base pair 88, 122, 982 to base pair 88, 128, 131.
• FABP1 is expressed abundantly in the human liver where it accounts for 7-11 % of the total cytosolic protein, and can also be found in the intestine, kidney, pancreas stomach and lung.
• Evaluation of increased levels of urinary and serum FABP1 have also shown to be effective markers in the detection of intestinal ischaemia, progressive end-stage renal failure and ischaemic damage caused by renal transplantation or cardiac bypass surgery.
• FABP1 is unique in the wider range of other hydrophobic ligands it can bind including bilirubin, monoglycerides, bile acids and fatty acyl CoA . It has been proposed that FABP1 plays a significant role in preventing cytotoxicity by binding heme, fatty acids and other molecules that are potentially toxic when unbound.
• FABP1 is unique in the wider range of other hydrophobic ligands it can bind including bilirubin, monoglycerides, bile acids and fatty acyl CoA . It has been proposed that FABP1 plays a significant role in preventing cytotoxicity by binding heme, fatty acids and other molecules that are potentially toxic when unbound.