halofantrine造句

• Lumefantrine is a relative of halofantrine that is used in some combination antimalarial regimens.
• Halofantrine's structure contains a substituted phenanthrene, and is related to the antimalarial drugs quinine and lumefantrine.
• Halofantrine has also been shown to bind to plasmpesin, a haemoglobin degrading enzyme unique to the malarial parasites.
• Halofantrine is not recommended for use in pregnancy and lactation, in small children, or in patients that have taken mefloquine previously.
• The most dangerous side effect is cardiac arrhythmias : halofantrine causes significant QT prolongation, and this effect is seen even at standard doses.
• The resistance of other quinolone anti-malarials such as amiodiaquine, mefloquine, halofantrine and quinine are thought to have occurred by similar mechanisms.
• Halofantrine was developed at SRI International for the Walter Reed Army Institute of Research from 1965 to 1975 by a team led by medicinal chemist William Colwell.
• A dose of 8 mg / kg of halofantrine is advised to be given in three doses at six-hour intervals for the duration of the clinical episode.
• He then pursed a career in academia and in the pharmaceutical industry discovering and developing new drugs for the treatment of parasitic diseases such as halofantrine in the treatment of multidrug resistant helminthic infections.
• Now, Cowman said his team has found direct proof that mutations in the gene give the parasite resistance to the drugs quinine, mefloquinine and halofantrine and also influence resistance to chloroquine and artemisinin.
• Albendazole and halofantrine received their regulatory approvals in the United States from the Food and Drug Administration under the trade names of Albenza?and Halfan?respectively and were licensed in a large number of countries around the world.
• Marketed as "'Halfan "', halofantrine is never used to prevent malaria and its mode of action is unknown, although a crystallographic study showed that it binds to hematin " in vitro ", suggesting a possible mechanism of action.
• In medicine and chemistry, SRI developed dry-powder drugs, laser photocoagulation ( a treatment for some eye maladies ), remote surgery ( also known as telerobotic surgery ), bio-agent detection using upconverting phosphor technology, the experimental anticancer drugs Tirapazamine and TAS-108, ammonium dinitramide ( an environmentally benign oxidizer for safe and cost-effective disposal of hazardous materials ), the electroactive polymer ( " artificial muscle " ), new uses for diamagnetic levitation, and the antimalarial drug Halofantrine.
• While working with Cavier in Paris, Rossignol had also searched for antimalarial agents with the Antimalarial Drug Development Program of the United States Army Research & Development Command based at the Walter Reed Army Institute of Research in Washington D . C . He completed the work initiated by the Army with the antimalarial, halofantrine, and conducted three well-controlled clinical studies in France, in Mali, a country in West Africa, and in French Guyana in South America for the treatment of drug-sensitive and drug-resistant Falciparum malaria, involving SmithKline & French Laboratories in the process.