hydroxypregnenolone造句

• The primary pathway involves conversion of 17?-hydroxypregnenolone to DHEA by way of 17, 20-lyase.
• Steroid precursors up to and including progesterone, 17?-hydroxypregnenolone, and especially 17?-hydroxyprogesterone accumulate in the adrenal cortex and in circulating blood.
• "' 17?-Hydroxypregnenolone "'is a pregnane ( C21 ) steroid that is obtained by hydroxylation of pregnenolone at the C17? position.
• The 21-acetate ester of 21-hydroxypregnenolone, prebediolone acetate, is described as a glucocorticoid and has been used in the treatment of rheumatoid arthritis.
• First, 3?-HSD II can convert enough of the excess 17?-hydroxypregnenolone to 17?-hydroxyprogesterone to produce 17?-hydroxyprogesterone levels suggestive of common 21-hydroxylase deficient CAH . Measurement of the other affected steroids distinguishes the two.
• Since 21-hydroxylase activity is not involved in synthesis of androgens, a substantial fraction of the large amounts of 17?-hydroxypregnenolone is diverted to synthesis of DHEA, androstenedione, and testosterone beginning in the third month of fetal life in both sexes.
• Medrogestone has been found to be an 3?-hydroxysteroid dehydrogenase / ? 5-4 isomerase " in vitro ", preventing conversion of pregnenolone to progesterone and 17?-hydroxypregnenolone to 17?-hydroxyprogesterone in rat testis preparations, and inhibits the biosynthesis of testosterone " in vivo " in rats.
• "' 3?-Hydroxysteroid dehydrogenase / ? 5-4 isomerase "'( "'3?-HSD "') ( ) is an enzyme that catalyzes the biosynthesis of progesterone from pregnenolone, 17?-hydroxyprogesterone from 17?-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone ( DHEA ) in the adrenal gland.