inflammasomes造句

• These proteins allow caspase-1 activation by forming a multiprotein activating complex called Inflammasomes.
• Together this results in an action potential in sensory neurons and the activation of inflammasomes.
• It binds onto the P2RX7 receptors of host antigen-presenting cells ( APCs ) and activates the inflammasomes.
• The P2X7 purinergic receptor is another receptor used by SAA1 for a number of cellular functions including the activation of NLRP3 inflammasomes.
• NALPs are implicated in the activation of proinflammatory caspases ( e . g ., CASP1 ) via their involvement in multiprotein complexes called inflammasomes.
• This causes the combined response of both a resulting action potential due to the depolarization created by the influx of calcium and potassium ions, and the activation of inflammasomes.
• For example, ICEBERG nucleates the formation of Caspase-1 filaments and is thus incorporated into the filaments, but lacks the ability to inhibit the activation of inflammasomes.
• Though they all interact with the inflammasomes using CARD CARD interactions, they differ in the way they carry out their inhibitory functions as well as in their effectiveness at doing so.
• Currently, her research interests include innate immunity, autophagy, inflammasomes, sexually transmitted infections, herpes simplex virus, human papillomavirus, respiratory virus infections, influenza infection, T cell immunity, and commensal bacteria.
• This viral DNA is sensed by gamma-interferon-inducible protein 16 ( IFI16 ), which produces an innate immune response against the virus by activating caspase 1 in IFI16 inflammasomes and inducing pyroptosis, a highly inflammatory form of programmed cell death.
• He has uncovered new molecules and biochemical processes that are triggered by sensors of infection and tissue injury, including the toll-like receptors and inflammasomes, and the signals they drive that stimulate inflammation, notably cytokines in the interleukin-1 family.
• It contains a catalytic domain with an active site that spans both the p20 and p10 subunits, as well as a noncatalytic Caspase Activation and Recruitment Domain ( NLR ) Family CARD Domain-Containing Protein 4 ( NLRC4 ) through CARD-CARD interactions in the formation of inflammasomes.
• Similarly, some POPs ( Pyrin only proteins ) are also known to regulate Caspase-1 activation through inhibition of inflammasome activation by binding to and blocking PYD interactions, which also play a role in the formation of the inflammasomes, though the exact mechanisms are not yet well established.
• These cells undergo abortive infection with HIV . Cell death is triggered when the host cell detects HIV foreign DNA intermediates and initiates a suicidal death pathway in an attempt to protect the host, leading to caspase-1 activation in inflammasomes, thus causing pyroptosis ( a highly inflammatory form of programmed cell death ).