lef1造句

• LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia.
• Some commonly studied MITF interactions include those with MAZR, PIAS3, Tfe3, hUBC9, PKC1, and LEF1.
• Lymphoid enhancer-binding factor-1 ( LEF1 ) is a 48-kD nuclear protein that is expressed in pre-HMG1 ).
• The researchers have found that some tumors in sebaceous glands contain mutations in LEF1, a transcription factor that leads to ?-catenin inhibition.
• This way, a " stapled " helical peptide derived from the natural ?-catenin binding motif found in LEF1 was sufficient for the complete inhibition of ?-catenin dependent transcription.
• Sox proteins bind to the sequence WWCAAW and similar sequences ( Tcf / Lef1 group of genes which also contain a sequence-specific high mobility group and have a similar sequence specificity ( roughly TWWCAAAG ).
• Genes expressed in the early dental epithelium in mice such as Bmp4, Bmp7, Dlx2, Dlx5, Fgf1, Fgf2, Fgf4, Fgf8, Lef1, Gli2, and Gli3 are also potential candidates.
• Studies investigating the role of plakoglobin in disease pathology have found that suppression of desmoplakin expression by siRNA led to the Wnt signaling via Tcf / Lef1 and ensued pathogenesis of ARVC . Specifically, adipogenic factor expression was induced and cardiac progenitor cells at the epicardium were differentiated to adipocytes.