meticillin造句

• Meticillin is actually a penicillinase-resistant B-lactam antibiotic.
• Like other beta-lactam antibiotics, meticillin acts by inhibiting the synthesis of bacterial cell walls.
• Half of all staph that circulates in hospitals is resistant to meticillin, the standard drug used to treat it.
• Meticillin is insensitive to beta-lactamase ( also known as penicillinase ) enzymes secreted by many penicillin-resistant bacteria.
• Meticillin is not bound and hydrolysed by penicillinase, meaning it can kill the bacteria, even if this enzyme is present.
• About half of all staph germs in hospitals are resistant to meticillin, the standard treatment, and are increasingly resistant to vancomycin.
• Resistance to meticillin is conferred by activation of a new bacterial penicillin binding protein ( PBP ) " mecA gene ".
• Meticillin is no longer manufactured because the more stable and similar penicillins such as oxacillin ( used for clinical antimicrobial susceptibility testing ), flucloxacillin, and dicloxacillin are used medically.
• Meticillin and other ?-lactam antibiotics are structural analogs of D-alanyl-alanine, and the transpeptidase enzymes that bind to them are sometimes called penicillin-binding proteins ( PBPs ).