oatp1b1造句

• OATP1B1 and OATP1B3 are known to play an important role in hepatic drug disposition.
• Single nucleotide polymorphisms ( SNPs ) are also associated with the OATPs; particularly OATP1B1.
• Among six major membrane transporters, recommended by US FDA, lobeglitazone interacts with OATP1B1, OAT3, and MDR1.
• Drug interactions was updated to include a statement that in vitro, dolutegravir was not a substrate of OATP1B1 or OATP1B3.
• The OATPs most associated with these interactions are OATP1B1, OATP1B3 and OATP2B1, which are all present on the hepatocyte basolateral ( sinusoidal ) membrane.
• Also in the " in vitro " studies, it was observed that eluxadoline is an " in vivo " substrate of OATP1B1, OAT3, and MRP2.
• Since tyrosine kinase inhibitors ( TKIs ) are metabolized in the liver, interaction of TKIs with OATP1B1 and OATP1B3 can be considered as important molecular targets for transporter mediated drug-drug interactions.
• Eluxadoline was not found to inhibit BCRP-, BSEP-, MRP2-, OCT1-, OCT2-, OAT1-, OAT3-, or OATP1B3-mediated transport of probe substrates but inhibited the transport of probe substrates of OATP1B1 and P-gp.