txa2造句

• Receptors that mediate TXA2 actions are thromboxane A2 receptors.
• The increase of cytosolic calcium also leads to shape change and TxA2 synthesis, leading to signal amplification.
• The human TXA2 receptor ( TP ) is a typical G protein-coupled receptor ( GPCR ) with seven transmembrane segments.
• Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production.
• These metabolites contain two double bonds and are named series 2 prostanoids, i . e . PGD2, PGE2, PGF2?, PGI2, TXA2 and PGH2.
• This non-enzymatic pathway may explain findings that cells can make 12-HHT in excess of TXA2 and also in the absence of active cycloxygenase and / or thromboxane synthase enzymes.
• Most work in the field of TXA2 is done instead with synthetic analogs such as U46619 and I-BOP . In human studies, 11-dehydrothromboxane B2 levels are used to indirectly measure TXA2 production.
• Most work in the field of TXA2 is done instead with synthetic analogs such as U46619 and I-BOP . In human studies, 11-dehydrothromboxane B2 levels are used to indirectly measure TXA2 production.
• "' Thromboxane A2 "'( TXA2 ) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties : it stimulates activation of new platelets as well as increases platelet aggregation.
• Excessive concentrations of TXA2 could lead to thrombosis, which when coupled with 25I-NBOMe's vasoconstrictive effect, is a major risk factor for cardiac ischemia, a dangerous condition the symptoms of which are present in several toxicological reports.
• After a vascular injury occurs, platelets are activated by locally exposed collagen ( glycoprotein ( GP ) VI receptor ), locally generated thrombin ( PAR1 and PAR4 receptors ), platelet-derived thromboxane A2 ( TxA2 ) ( TP receptor ) and ADP ( P2Y1 and P2Y12 receptors ) that is either released from damaged cells or secreted from platelet dense granules.
• TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2.12-HHT, while once thought to be an inactive byproduct of TXA2 synthesis, has recently been shown to have a range of potentially important actions, some of which relate to the actions of TXA2 ( see 12-Hydroxyheptadecatrienoic acid ).
• TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2.12-HHT, while once thought to be an inactive byproduct of TXA2 synthesis, has recently been shown to have a range of potentially important actions, some of which relate to the actions of TXA2 ( see 12-Hydroxyheptadecatrienoic acid ).
• TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2.12-HHT, while once thought to be an inactive byproduct of TXA2 synthesis, has recently been shown to have a range of potentially important actions, some of which relate to the actions of TXA2 ( see 12-Hydroxyheptadecatrienoic acid ).
• The many other actions of 12 ( " S " )-HETE ( see 12-Hydroxyeicosatetraenoic acid ) and any other ligands found to interact with this receptor will require studies similar those conducted on PC3 cells and mesenteric arteries to determine the extent to which they interact with BLT2, TXA2 / PGH2, and PPARgamma receptors and thereby may contribute in part or whole to their activity.