tykerb造句

• Pharmaceutical company GlaxoSmithKline ( GSK ) markets the drug under the propriety names Tykerb ( mostly U . S . ) and Tyverb ( mostly Europe and Russia ).
• On the August 2, 2013, India's Intellectual Property Appellate Board revoked the patent for Glaxo's Tykerb citing its derivative status, while upholding at the same time the original patent granted for lapatinib.
• Approval was based on the EMILIA study, a phase III clinical trial that compared trastuzumab emtansine versus capecitabine ( Xeloda ) plus lapatinib ( Tykerb ) in 991 people with unresectable, locally advanced or metastatic HER2-positive breast cancer who had previously been treated with trastuzumab and taxane chemotherapy.
• Overall, trastuzumab emtansine was better tolerated than the control treatment, a combination of lapatinib ( Tykerb ) and capecitabine ( Xeloda ), with 43 % of patients in the trastuzumab emtansine group experiencing severe toxic effects, versus 59 % of those who received lapatinib / capecitabine; furthermore, fewer patients had to stop treatment due to adverse effects than with lapatinib or capecitabine.