Dendritic cells ( dc ) are the most potent professional antigen - presenting cells ( apc ) , required for the initiation of immune response . for all that the mechanism of dc functions are not fully elucidated
Up to now , clinical trails have been conducted in u . s . a . and europe to observe the antitumor effects of exosomes . exosomes may be a kind of potential vaccines for tumors in future . on the other hand , exosomes may be a kind of tolerogenic materials
Dendritic cells are characterized by their ability to efficiently present antigen , and are uniquely equipped to stimulate naive t cell responses . immature dendritic cells acquire antigens from throughout the peripheral body , then migrate to t - lymphocyte - dependent areas of lymph nodes . thus , dendritic cells act as bridges , operating at the interface of innate and acquired immunity
Dcs play a pivotal role in the development of antitumor immunity . t lymphocytes immune response induced by direct antigen - pulsed dcs can not maintain longer for peptides - mhc department or mhc molecules degeneration . the method of dcs loading with tumor antigen gene is another potential approach to enhancing and maintaining immune response
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